Intermittent Hypoxia and Human Diseases
The scientific field of intermittent hypoxia and its effects on living organisms is surrounded by divergent and controversial findings. Does the condition play pathogenic roles in disease states, such as sleep apnea, chronic pulmonary disease, cardiovascu
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Lei Xi • Tatiana V. Serebrovskaya Editors
Intermittent Hypoxia and Human Diseases
Editors Lei Xi, M.D. Department of Internal Medicine Virginia Commonwealth University Richmond Virginia USA
Tatiana V. Serebrovskaya, Ph.D., D.Sc. Bogomoletz Institute of Physiology National Academy of Sciences Kiev Ukraine
ISBN 978-1-4471-2905-9 ISBN 978-1-4471-2906-6 DOI 10.1007/978-1-4471-2906-6 Springer Dordrecht Heidelberg New York London
(eBook)
Library of Congress Control Number: 2012937844 British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library © Springer-Verlag London 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
What is “intermittent hypoxia”? Does it play pathogenic roles in disease states, such as sleep-disordered breathing (sleep apnea), chronic pulmonary disease, cardiovascular disease, and cancer? Or, quite to the contrary, does exposure to intermittent hypoxia induce protective responses? As the 25 chapters of this excellent collection attest, “intermittent hypoxia” means different things to different investigators. Depending upon what is meant by this phrase, and in what context it occurs, the effect may be detrimental or beneficial. In some cases, “intermittent hypoxia” refers to
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