Drosophila Models for Human Diseases
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosoph
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Masamitsu Yamaguchi Editor
Drosophila Models for Human Diseases
Advances in Experimental Medicine and Biology Volume 1076 Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Masamitsu Yamaguchi Editor
Drosophila Models for Human Diseases
Editor Masamitsu Yamaguchi Department of Applied Biology Kyoto Institute of Technology Kyoto, Japan
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-13-0528-3 ISBN 978-981-13-0529-0 (eBook) https://doi.org/10.1007/978-981-13-0529-0 Library of Congress Control Number: 2018947577 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Fifteen years ago when I gave a talk on “Drosophila models for human diseases” to medical doctors, they were not particularly interested in this subject. They said that even for mouse models it was hard to interpret the results, so that flies must be even more difficult. When I gave the equivalent talk to Drosophila communities at a similar time, they were also not very interested in the subject of “Drosophila models for human diseases.” They were more interested in basic biological and/or developmental processes and evolutionary genetics. However, now the situation
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