Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morpholog
- PDF / 1,059,013 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 35 Downloads / 166 Views
Genes & Genomics https://doi.org/10.1007/s13258-020-00984-y
RESEARCH ARTICLE
Genome‑wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography Agraw Amane1,2,3,4 · Gurja Belay1 · Yao Nasser3 · Martina Kyalo3 · Tadelle Dessie4 · Adebabay Kebede2 · Tesfaye Getachew5 · Jean‑Baka Domelevo Entfellner3 · Zewdu Edea6 · Olivier Hanotte4,9 · Getinet Mekuriaw Tarekegn7,8 Received: 10 January 2020 / Accepted: 4 August 2020 © The Author(s) 2020
Abstract Background Ethiopian sheep living in different climatic zones and having contrasting morphologies are a most promising subject of molecular-genetic research. Elucidating their genetic diversity and genetic structure is critical for designing appropriate breeding and conservation strategies. Objective The study was aimed to investigate genome-wide genetic diversity and population structure of eight Ethiopian sheep populations. Methods A total of 115 blood samples were collected from four Ethiopian sheep populations that include Washera, Farta and Wollo (short fat-tailed) and Horro (long fat-tailed). DNA was extracted using Quick-DNA™ Miniprep plus kit. All DNA samples were genotyped using Ovine 50 K SNP BeadChip. To infer genetic relationships of Ethiopian sheep at national, continental and global levels, genotype data on four Ethiopian sheep (Adilo, Arsi-Bale, Menz and Black Head Somali) and sheep from east, north, and south Africa, Middle East and Asia were included in the study as reference. Results Mean genetic diversity of Ethiopian sheep populations ranged from 0.352 ± 0.14 for Horro to 0.379 ± 0.14 for ArsiBale sheep. Population structure and principal component analyses of the eight Ethiopian indigenous sheep revealed four distinct genetic cluster groups according to their tail phenotype and geographical distribution. The short fat-tailed sheep did not represent one genetic cluster group. Ethiopian fat-rump sheep share a common genetic background with the Kenyan fat-tailed sheep. Conclusion The results of the present study revealed the principal component and population structure follows a clear pattern of tail morphology and phylogeography. There is clear signature of admixture among the study Ethiopian sheep populations Keywords Fat-tail · Genetic diversity · Ovine 50 K SNP · Population structure
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13258-020-00984-y) contains supplementary material, which is available to authorized users. * Agraw Amane [email protected] * Gurja Belay [email protected] * Getinet Mekuriaw Tarekegn [email protected] Extended author information available on the last page of the article
Given its proximity to the Arabian Peninsula, Ethiopia is considered as a corridor for the introduction of livestock species including sheep to the African continent (Hanotte et al. 2002; Muigai and Hanotte 2013). Sheep and their products play a critical role in the livelihood of millions of farmers an
Data Loading...
