Giant hepatic adenoma with bone marrow metaplasia not associated with oral contraceptive intake
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Case report
Giant hepatic adenoma with bone marrow metaplasia not associated with oral contraceptive intake Giovanni Ramacciato1, Giuseppe R Nigri*1, Paolo Aurello1, Francesco D'Angelo1, Francesca Pezzoli1, Simone Rossi1, Emanuela Pilozzi2, Giorgio Ercolani3 and Matteo Ravaioli3 Address: 1Hepatobiliary-pancreatic Surgery, Department of Surgery, University of Rome "La Sapienza", II School of Medicine, St. Andrea Hospital, Rome, Italy, 2Department of Pathology, University of Rome "La Sapienza", II School of Medicine, St. Andrea Hospital, Rome, Italy and 3Liver and Multivisceral Transplantation Unit, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy Email: Giovanni Ramacciato - [email protected]; Giuseppe R Nigri* - [email protected]; Paolo Aurello - [email protected]; Francesco D'Angelo - [email protected]; Francesca Pezzoli - [email protected]; Simone Rossi - [email protected]; Emanuela Pilozzi - [email protected]; Giorgio Ercolani - [email protected]; Matteo Ravaioli - [email protected] * Corresponding author
Published: 25 August 2006 World Journal of Surgical Oncology 2006, 4:58
doi:10.1186/1477-7819-4-58
Received: 17 May 2006 Accepted: 25 August 2006
This article is available from: http://www.wjso.com/content/4/1/58 © 2006 Ramacciato et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Hepatocellular adenomas are the most common benign liver tumors. They are usually related to oral contraceptive intake. Case presentation: This case describes a 58-year-old woman admitted to our institution for a hepatic mass incidentally discovered during a routine examination. The patient, who was never on oral contraceptives, was asymptomatic upon admission. She underwent a thorough diagnostic evaluation and then a hepatic right trisegmentectomy. The histologic evaluation of the mass showed that it was a hepatocellular adenoma with areas of bone marrow metaplasia. Conclusion: Bone marrow metaplasia has rarely been found associated to liver tumors. The presence of marrow-derived hepatic progenitor cells might be the source of both adenoma hepatocytes and bone marrow differentiated cells. To our knowledge, this is only the second case in the English literature in which areas of bone marrow metaplasia were found in a hepatocellular adenoma.
Background Hepatocellular adenomas are considered the most common benign liver tumors. They are proliferative lesions arising from hepatocyte. They occur primarily in women between 20 to 40 years of age and are usually related to oral contraceptive intake. Even though the hepatic adenoma is not a malignant tumor, surgical intervention may be required to establish a histological diagnosis of the
liver mass or
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