Atlas of Bone Marrow Pathology

Examination of the bone marrow has always been, and to-date techniques whose application will undoubtedly to a large extent still is, within the domain of the haema­ increase in the future. tologist. This is because smears of bone marrow aspirates After l

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Cu rrent Histopathology Consultant Editor

Professor G. Austin Gresham, TO, SeD, MD, FRCPath.

Professor of Morbid Anatomy and Histology, University of Cambridge

Volume Fifteen

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BONEMARROW PATHOLOGY BY B. FRISCH

Institute of Haematology Ichilov Hospital and Sackler Faculty of Medicine, Tel-Aviv University Israel

R. BARTL

Bone Marrow Diagnosis Dept. of Internal Medicine "Innenstadt". University of Munich FRG Immunohistology on cryostat sections in collaboration with Dr C. SCHMID, Institute of Pathologic Anatomy, University of Graz, Austria. Studies on paraffin-embedded biopsies in collaboration with Dr N. HURWITZ, Institute of Pathology, Kaplan Hospital. Rehovoth, Israel .

• • KLUWER ACADEMIC PUBLISHERS .~ DORDRECHT/BOSTON/LONDON

Distributors

British Library Cataloguing in Publication Data

for the United States and Canada: Kluwer Academic Publishers, PO Box 358, Accord Station, Hingham, MA 02018-0358, USA for all other countries: Kluwer Academic Publishers Group, Distribution Center, PO Box 322, 3300 AH Dordrecht. The Netherlands

Frisch, B. (Bertha) Atlas of bone marrow pathology. 1. Man. Bone marrow. Diseases I. Title II. Bartl. R. (Reiner) III. Series 616.4'1 ISBN-13: 978-94-010-6808-6

Copyright

© 1990 by

e-ISBN-13: 978-94-009-0717-1

001: 10.1007/978-94-009-0717-1

B. Frisch and R. Bartl

Library of Congress Cataloging-in-Publication Data

Softcover reprint of the hardcover 1st edition 1990

Frisch, B. (Bertha) Atlas of bone marrow pathology / by B Frisch, R. Bartl. p. cm. - (Current histopathology; v. 15) Includes bibliographical references.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers, Kluwer Academic Publishers BV, PO Box 17, 3300 AA Dordrecht. The Netherlands.

1. Bone marrow - Histopathology - Atlases. I. Bartl, R. (Reiner) II. Title III. Series. [DNLM: 1. Bone Marrow Diseases - atlases. W1 CU788J BA v. 15/ WH 17 F917a] RC645.7.F741989 616.4'1 - dc20 DNLM/DLC for Library of Congress 89-20102 CIP

Published in the United Kingdom by Kluwer Academic Publishers, PO Box 55, Lancaster, UK. Kluwer Academic Publishers BV incorporates the publishing programmes of D. Reidel, Martinus Nijhoff, Dr W. Junk and MTP Press. Typeset and originated by Speedlith Photolitho Ltd., Longford Trading Estate, Thomas Street. Stretford, Manchester M32 OJT Bound by Butler and Tanner Ltd., Frome and London

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Contents

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2 3 4

5 6 7 8 9 10 11

Series Ed itor' s Foreword Introduction Biology, structure and components of normal bone marrow Hypoplasias (aplasias) Hyperplasias Stromal reactions in hypoplasias and inflammatory conditions (infections) Primary and secondary myelodysplastic syndromes Acute leukaemias Chronic myeloproliferative disorders Lymphoproliferations in the bone marrow The mononuclear phagocyte system (reticuloendothelial system) Metastases in the bone marrow Bone marrow in osteopathies Ind