Bone Marrow Failure
This book presents the latest scientific knowledge on inherited and acquired bone marrow failure syndromes, describing the advances in understanding of genetics and pathophysiology that have been achieved as a result of high-throughput DNA sequencing, RNA
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Gary M. Kupfer · Gregory H. Reaman Franklin O. Smith Editors
Bone Marrow Failure
Pediatric Oncology Series Editors: Gregory H. Reaman Silver Spring, MD, USA Franklin O. Smith Cincinnati, OH, USA
More information about this series at http://www.springer.com/series/5421
Gary M. Kupfer • Gregory H. Reaman Franklin O. Smith Editors
Bone Marrow Failure
Editors Gary M. Kupfer Department of Pediatrics Yale School of Medicine New Haven, CT USA
Gregory H. Reaman Department of Pediatrics George Washington University Washington, DC USA
Franklin O. Smith Medpace Cincinnati, OH USA
ISSN 1613-5318 ISSN 2191-0812 (electronic) Pediatric Oncology ISBN 978-3-319-61420-5 ISBN 978-3-319-61421-2 (eBook) https://doi.org/10.1007/978-3-319-61421-2 Library of Congress Control Number: 2018950518 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
For many years, bone marrow failure was a pathological entity, all thrown into the same bin without thought to pathogenesis, diagnosis, prognosis, and, certainly, treatment. Forward to the age of blood banking, advanced pharmacology, imaging, and other trappings of modern medicine, the full flower of the diversity of these diseases became apparent. Now, in 2018, with DNA sequencing occurring at the highest technical level, cheapest price, and overwhelming volume, a blizzard of genes that account for these varying syndromes has come into focus, with the science of investigating the function of these genes following close on the heels of this information. In this volume we lay out a compendium of chapters outlining the bone marrow failure syndromes. Rather
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