Glioma Principles and Practice in Neuro-Oncology
Many recent developments in neuro-oncology relevant to clinical practice have contributed to improved patient care. The most im portant impact of these developments on treatment may have been a change in the attitudes of the neuro-oncologists involved in
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(Eds.)
GLIOMA Principles and Practice in Neuro-Oncology
With 62 Figures and 38 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Dr. A. B. M. F. Karim Department of Radiation Oncology, Free University Hospital, P.O. Box 7057, The Netherlands 1007 MB Amsterdam
Dr. Edward R. Laws, Jr. Department of Neurological Surgery, George Washington University Medical Center, 2150 Pennsylvania Ave. NW, Washington DC 20037, USA
ISBN-13: 978-3-540-52286-7 e- ISBN-13: 978-3-642-84127-9 DOl: 10.1007/978-3-642-84127-9 Library of Congress Cataloging-in-Publication Data Glioma: principles and practice in neuro-oncology 1A.B.M.F. Karim, E.R. Laws, Jr. (eds.). Includes index. ISBN-I3: 978-3-540-52286-7 1. Gliomas. I. Karim; Abul Bashr Mohammed FazluI. II. Laws, Junior, Edward R. [DNLM: 1. Brain Neoplasms - diagnosis. 2. Brain Neoplasms-therapy. 3. Glioma. WL 358 G5607] RC280.B7G581991 616.99'281-dc20 DNLM/DLC for Library of Congress 91-4599CIP . This work is subject to copyright. AIl rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is ouly permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and a copyright fee mnst always be paid.
© Springer-Verlag Berlin Heidelberg 1991 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typesetting: Briihlsche U niversitiitsdruckerei, Giessen 27/3020-543210- Printed on acid-free paper
Preface
Many recent developments in neuro-oncology relevant to clinical practice have contributed to improved patient care. The most important impact of these developments on treatment may have been a change in the attitudes of the neuro-oncologists involved in making decisions regarding patients with gliomas. From an era of uncertainty which led to therapeutic nihilism, we have entered one of active interventions based on objective parameters for the treatment of gliomas, which may be either slow-growing or rapid killers. The histopathological characteristics of gliomatous lesions are intriguing, and it is only recently that a clearer picture has begun to emerge. A group of dedicated neuropathologists has been attempting to reach a consensus on pathological classification and grading, providing an important landmark in the field of neurooncology. This book does not mean to provide exhaustive details on the histopathology of gliomas
