Glutamate and Addiction
The past decade has witnessed a growing body of preclinical and clinical evidence that glutamatergic systems may play a pivotal role in drug dependence. In Glutamate and Addiction, world-renowned scientific experts critically review all of this evidence a
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C ontemporary C linical N euroscience
Series Editors: Ralph Lydic and Helen A. Baghdoyan
Genetics and Genomics of Neurobehavioral Disorders, edited by Gene S. Fisch, 2003 Sedation and Analgesia for Diagnostic and Therapeutic Procedures, edited by Shobha Malviya, Norah N. Naughton, and Kevin K. Tremper, 2003 Neural Mechanisms of Anesthesia, edited by Joseph F. Antognini, Earl E. Carstens, and Douglas E. Raines, 2002 Glutamate and Addiction edited by Barbara Herman, 2002 Molecular Mechanisms of Neurodegenerative Diseases edited by Marie-Françoise Chesselet, 2000
Contemporary Clinical Neuroscience
GLUTAMATE AND ADDICTION Edited by
BARBARA H. HERMAN,
PhD
Clinical Medical Branch, Division of Treatment Research and Development National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) Bethesda, MD Coeditors
Jerry Frankenheim, PhD Pharmacology, Integrative & Cellular Neurobiology Research Branch (PICNRB) Division of Neuroscience & Behavioral Research (DNBR), National Institute on Drug Abuse (NIDA) National Institutes of Health (NIH), Bethesda, MD
Raye Z. Litten, PhD Treatment Research Branch, Division of Clinical and Prevention Research National Institute on Drug Abuse (NIAAA), National Institutes of Health (NIH), Bethesda, MD
Philip H. Sheridan, MD Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research Office of Drug Evaluation I, Food and Drug Administration, Rockville, MD
Forrest F. Weight, MD Laboratory of Molecular and Cellular Neurobiology, Division of Intramural Clinical and Biological Research, National Institute on Drug Abuse (NIAAA) National Institutes of Health (NIH) Bethesda, MD
Steven R. Zukin, MD Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA) National Institutes of Health (NIH), Bethesda, MD
SPRIN G ER SCIEN CE+BU SIN ESS M ED IA , LLC
© 2002 Springer Science+Business Media New York Originally published by Humana Press Inc in 2002 Softcover reprint of the hardcover 1st edition 2002
All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of pu
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