Glutamate Receptors Methods and Protocols
This volume aims to provide clear and detailed methods to probe glutamate receptor function. Chapters in this book feature methods to study synaptic ultrastructure, receptor dynamics/receptor interactions and trafficking, cellular plasticity, receptor gen
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Corinna Burger Margaret Jo Velardo Editors
Glutamate Receptors Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Glutamate Receptors Methods and Protocols
Edited by
Corinna Burger Department of Neurology, University of Wisconsin, Madison, WI, USA
Margaret Jo Velardo ANSER, Homeland Security Studies and Analysis Institute, Falls Church, VA, USA
Editors Corinna Burger Department of Neurology University of Wisconsin Madison, WI, USA
Margaret Jo Velardo ANSER Homeland Security Studies and Analysis Institute Falls Church, VA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9076-4 ISBN 978-1-4939-9077-1 (eBook) https://doi.org/10.1007/978-1-4939-9077-1 Library of Congress Control Number: 2018967452 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The discovery of glutamate receptors (GluRs) in neurons and glia in the central nervous system and identification of the roles of ionotropic glutamate receptors in mediating fast excitatory synaptic transmission, followed by studies implicating metabotropic glutamate receptors in metaplasticity, are some of the seminal neuroscience findings of the twentieth century. And, as their structure and function has been elucidated, this phenomenal suite of receptor families has only grown in scientific importance and significance. Over the past four decades, a tremendous body of work has provided the detai
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