Gold nanoparticles anchored graphitized carbon nanofibers ionic liquid electrode for ultrasensitive and selective electr
- PDF / 3,268,227 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 203 Views
ORIGINAL PAPER
Gold nanoparticles anchored graphitized carbon nanofibers ionic liquid electrode for ultrasensitive and selective electrochemical sensing of anticancer drug irinotecan Hossieny Ibrahim 1
&
Yassien Temerk 1
Received: 5 May 2020 / Accepted: 13 September 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract An electrochemical sensor is described for highly sensitive and selective determination of anticancer drug irinitecan (IRT). Gold nanoparticles anchored graphitized carbon nanofibers (Au@GCNFs) was prepared. Au@GCNFs was characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray. The combination of high catalytic activity of the nanocomposite Au@GCNFs and the good conductivity ionic liquid [BMIM]PF6 (IL) resulted in a modified paste electrode (IL/Au@GCNFs-PE). The IL/Au@GCNFs-PE exhibits excellent electrocatalytic activity for selective determination of IRT in the presence of physiological electroactive species, such as ascorbic acid (AA), dopamine (DA), uric acid (UA), and caffeine (CAF) mixture, typically at working potential of 0.88 V vs. Ag/AgCl. The linear response ranges 4.0 nM– 1.79 μM and 4.5 nM–1.57 μM with limits of detection of 1.55 nM and 1.70 nM were calculated for IRT in the absence and presence of the quaternary mixture, respectively. The sensor is reproducible and stable over four weeks, and interference by biologically essential compounds is negligible. The method was applied to the determination of IRT in pharmaceutical formulations, in spiked blood serum and urine, and in clinical patient blood. The recovery values ranged from 96.0 to 104.2%. Keywords Irinotecan . Clinical samples . Carbon nanofibers . Electrochemical sensor
Introduction Carbon nanomaterials have received a great deal of interest because of their excellent properties, appropriate for applications in electrochemical sensors. Graphitized carbon nanofibers (GCNFs) are considered one of the appropriate supporting carbon nanomaterials due to its large surfaces-tovolume ratio, excellent electrical conductivity, and electrocatalytic activity. GCNFs have a cylindrical nanostructure with graphene sheet stacking arrangement [1]. Interestingly, it has Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-020-04560-9) contains supplementary material, which is available to authorized users. * Hossieny Ibrahim [email protected]; [email protected] * Yassien Temerk [email protected]; [email protected] 1
Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
defects on its outer surface that greatly improve the efficiency of an electron transfer on the electrode surface [2, 3]. However, the use of GCNFs in this analysis has numerous limitations such as low sensitivity and selectivity, and therefore, nanocomposites are fabricated to overcome these disadvantages. Nanomaterials based on the gold nanoparticles (AuNPs) have opened a new window to the fabricat
Data Loading...
