Head and body/tail pancreatic neuroendocrine tumors have different biological characteristics and clinical outcomes
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ORIGINAL ARTICLE – CLINICAL ONCOLOGY
Head and body/tail pancreatic neuroendocrine tumors have different biological characteristics and clinical outcomes Wentong Mei1,2 · Yixuan Ding1,2 · Shuo Wang1,2 · Yuchen Jia1,2 · Feng Cao1,2 · Fei Li1,2 Received: 30 April 2020 / Accepted: 24 June 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The incidence of pancreatic neuroendocrine tumors (pNETs) has continued to increase, but for pNETs, there is still no distinction between treatments based on anatomical location. We aim to determine whether NETs located at the head and body/tail of the pancreas are different. Patients and methods Within the Surveillance, Epidemiology, and End Results database (2004–2016), we focused on pNETs patients with comprehensive information. The patients were divided into two groups based on tumors’ location. We compared the characteristics of the two groups and assessed the risk factors for lymphatic metastasis. Survival analysis was performed based on the biological characteristics of the tumor. Results In all 3011 patients, pNETs were more common in the body/tail (62.94%) than in the head (37.06%) of the pancreas. The risk factors for lymph node metastasis in the two groups were different. Nonmetastatic, low-grade pancreatic body/tail NETs had the best prognosis (p
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