Neuroendocrine Tumors
New research has shown that neuroendocrine tumors are more common than previously thought. Progress in our understanding of the molecular pathogenesis of these not-so-rare cancers has resulted in renewed interest in developing innovative therap
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James C. Yao Paulo M. Hoff Ana O. Hoff ●
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Editors
Neuroendocrine Tumors
Editors James C. Yao, MD Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston, TX, USA [email protected]
Paulo M. Hoff, MD Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, and Hospital Sirio Libanes São Paulo, Brazil [email protected]
Ana O. Hoff, MD Endocrine Neoplasia Unit Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Department of Endocrinology, Fleury Group, São Paulo, Brazil [email protected]
ISBN 978-1-60327-996-3 e-ISBN 978-1-60327-997-0 DOI 10.1007/978-1-60327-997-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011931712 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Neuroendocrine tumors arise from cells dispersed throughout the body. Historically, they have been thought to be a group of very rare and indolent diseases capable of causing a variety of esoteric hormonal syndromes. Over the past decade, a number of major advances were made in our understanding of the epidemiology and molecular biology of these not-so-rare tumors. Although several studies have demonstrated a significant heterogeneity among neuroendocrine tumors by primary site and proliferative rate, recent analyses of the population-based registries confirm a consistent and continuing rise in its incidence. Further, because of the relative longer survival enjoyed by patients with this disease, it is now recognized that the prevalence of neuroendocrine tumors exceeds 100,000 individuals in the United States alone. Neuroendocrine tumors are often well differentiated and associated with an indolent clini
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