Heat Shock Proteins 70 in Cellular Stress: Fight or Flight
Heat shock proteins (Hsp) are a family of proteins and the major chaperons of the cells. Hsp70 assists in folding and correct misfolded protein, improve the cellular transportation of proteins, reducing toxic proteins aggregation and act as a buffering sy
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Abstract Introduction Heat shock proteins (Hsp) are a family of proteins and the major chaperons of the cells. Hsp70 assists in folding and correct misfolded protein, improve the cellular transportation of proteins, reducing toxic proteins aggregation and act as a buffering system against cellular stressors either extrinsic or intrinsic stimuli. Methods A literature-based collection of articles in the available search engines (PubMed and Google Scholar). Results We show the critical roles of Hsp70 in balancing cell survival through corrections of misfolded proteins that are associated with apoptosis and toxicological effects on the cells. Conclusion Hsp70 is a cornerstone not only for chaperones but also for several essential functions of the cells and further investigations are required for developing therapeutic agents targeting this critical molecule. Keywords Apoptosis · Cells · Chaperons · Hsp · Immunity · Toxicology
M. M. A. Hussein (*) Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt I. M. Saadeldin Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt Department of Animal Production, College of Food and Agriculture Science, King Saud University, Riyadh, Saudi Arabia M. M. Ahmed Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt © Springer Nature Switzerland AG 2020 A. A. A. Asea, P. Kaur (eds.), Heat Shock Proteins, https://doi.org/10.1007/7515_2020_37
M. M. A. Hussein et al.
Abbreviations AIF Apaf1 APC Ask-1 BAD CARD CD CTL Cytc DC DISC ER ERK FADP GM-CSF GPI GRP HSBP HSF HSP IKK-β IRS-1 JAK JNK LBs LIF MAPK MCP MDscs MHC MIP MKK4 MOMP MyD88 NEF NF-IL6 NF-kB PD PKC STAT TLR TNF α Syn
Apoptosis-inducing factor Apoptosis protease activating factor-1 Antigen-presenting cell Apoptosis signal regulatory kinase -1 Bcl-2 associated death promoter protein Caspase recruitment domain Cluster of differentiation Cytotoxic T-cell Cytochrome c Dendritic cell Death inducing signaling complex Endoplasmic reticulum Extracellular signal-regulated kinase Fas-associated death domain protein Granulocyte-macrophage colony-stimulating factor Glycosyl phosphatidylinositol Glucose regulatory protein Heat shock binding protein Heat shock factor Heat shock protein Inhibitor of nuclear factor kappa-B kinase subunit beta Insulin receptor substrate -1 Janus kinase c-Jun N-terminal kinase Lewy bodies Leukemia inhibitory factor Mitogen-activated protein kinase Monocyte chemoattractant protein Myeloid-derived suppressor cells Major histocompatibility cell Macrophage inflammatory protein Mitogen-activated protein kinase -4 Mitochondrial outer membrane permeabilization Myeloid differentiation primary response Nucleotide exchange factor Nuclear factor interleukin-6 Nuclear factor kappa light chain enhancer of activated B cells Parkinson’s disease Protein kinase -c Signal transducer and activator transcription Toll-like receptor Tumor necrotic factor Alfa synuclein
Heat Shock Proteins and C
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