Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary Car
Hepatocellular Carcinoma: Targeted Therapy provides a detailed repository of the latest information regarding HCC epidemiology, diagnosis, imaging, pathology, staging, and treatment options. This volume also provides an up-to-date guide for treatment that
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Kelly M. McMasters Jean-Nicolas Vauthey Editors
Hepatocellular Carcinoma Targeted Therapy and Multidisciplinary Care
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Editors Kelly M. McMasters, MD, PhD Department of Surgery University of Louisville Louisville, KY, USA [email protected]
Jean-Nicolas Vauthey, MD Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston, TX, USA [email protected]
ISBN 978-1-60327-521-7 e-ISBN 978-1-60327-522-4 DOI 10.1007/978-1-60327-522-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010931163 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
It is a great pleasure and an honor to write the preface for this outstanding book dedicated to the therapy of hepatocellular carcinoma (HCC). This tumor, which is a major health problem worldwide, has stimulated the energy of several disciplines. The liver is a massive and complex organ requiring an excellent knowledge of its anatomy and physiology, with an exquisite comprehension of its impact on cardiovascular, pulmonary, and renal function. Initially, the treatment of HCC was limited to surgical approaches with liver resection being the only option with curative intent. The development of HCC in chronic liver disease was associated with a high risk of technical difficulties and a high morbidity/mortality rate. This has challenged liver surgeons to improve their knowledge regarding liver anatomy, assessment of liver function, use of intraoperative imaging, tolerance of vascular clamping, and better anticipation of postoperative liver recovery. As shown in several chapters of this book, progress in liver surgery for HCC has expanded its development, yielding a true specialty. Imaging of liver parenchyma was motivated by two different goals including an efficient screening along with an accurate evaluation of the tumor in a background of abnorma
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