Heterocycles via Cross Dehydrogenative Coupling Synthesis and Functi

This book discusses the developments in the synthesis and functionalization of different heterocycles based on the formation of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds using cross-dehydrogenative coupling (CDC). Consisting of 13 chapters, th

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erocycles via Cross Dehydrogenative Coupling Synthesis and Functionalization

Heterocycles via Cross Dehydrogenative Coupling

Ananya Srivastava Chandan K. Jana •

Editors

Heterocycles via Cross Dehydrogenative Coupling Synthesis and Functionalization

123

Editors Ananya Srivastava National Institute of Pharmaceutical Education and Research Guwahati, Assam, India

Chandan K. Jana Indian Institute of Technology Guwahati Guwahati, Assam, India

ISBN 978-981-13-9143-9 ISBN 978-981-13-9144-6 https://doi.org/10.1007/978-981-13-9144-6

(eBook)

© Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Preface

Carbon–carbon and carbon–heteroatom bond formation plays a central role in many chemical syntheses, and revolutions in these reactions will intensely improve the overall synthetic efficiency. This book describes the studies of past several years for the synthesis and functionalization of different heterocycles by making carbon– carbon (C-C) and carbon–heteroatom (C-X) bonds via cross-dehydrogenative coupling (CDC) of C-H and C-H or X-H. CDC, representing a new state of the art in the field of organic chemistry, expedites the synthesis and functionalization of heterocycles to provide architecturally more complex heterocyclic molecules which are the important constituents of most of the biologically active molecules, agrochemicals, etc. These methods offer an alternative to the separate steps of prefunctionalization and defunctionalization that have traditionally been part of the synthetic design. Therefore, in view of step and atom economies, direct utilization of C-H and X-H bonds without preactivation has gained enormous attention