High Prevalence of Cervical High-Risk Human Papillomavirus Harboring Atypical Genotypes in Human Immunodeficiency Virus
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ORIGINAL PAPER
High Prevalence of Cervical High‑Risk Human Papillomavirus Harboring Atypical Genotypes in Human Immunodeficiency Virus ‑Infected and ‑Uninfected First‑Generation Adult Immigrant Women Originating from Sub‑Saharan Africa and Living in France Ralph‑Sydney Mboumba Bouassa1,2,3,4 · Camelia Gubavu5 · David Veyer1,2 · Leman Robin1,2 · Anne Gravier5 · Laurent Hocqueloux5 · Thierry Prazuck5 · Hélène Péré1,2,4 · Laurent Bélec1,2,4 · for the ANRS ImmiPap Study Group
© The Author(s) 2020
Abstract Human papillomavirus (HPV)-related cervical lesions in first-generation immigrant African women in France should reflect the epidemiology of high-risk (HR)-human papillomavirus (HPV) infection in sub-Saharan Africa. First-generation immigrant African women attending the Centre Hospitalier Régional of Orléans, France, were prospectively subjected to endocervical swabs for HPV DNA PCR and Pap smear. Fifty women (mean age, 41.7 years) living in France (mean stay, 10.7 years) were enrolled, including 26.0% of HIV-negative women from general population and 74.0% of women with known HIV infection. Cervical HPV prevalence was 68.0%, with 56.0% of HR-HPV. HR-HPV -68 and -58 were the predominant genotypes (20.0% and 14.0%, respectively). HR-HPV-16 and HR-HPV-18 were infrequently detected. HIV-infected women showed a trend to be more frequently infected by HPV than HIV-negative women (70.3% versus 61.5%). Most women (84.0%) showed normal cytology, while the remaining (16.0%) exhibited cervical abnormalities and were frequently HIV-infected (87.5%). These observations highlight the unsuspected high burden of cervical HR-HPV infections mostly associated with atypical genotypes, HIV infection and cervical abnormalities in first-generation immigrant African women living in France. Keywords Human papillomavirus · First-generation · Immigrant women · Sub-saharan africa · France · Human immunodeficiency virus · Cervical cancer The members of the ANRS ImmiPap Study Group are listed in Acknowledgement section. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10903-020-01074-7) contains supplementary material, which is available to authorized users. * Laurent Bélec [email protected] 1
Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France
2
Faculté de Médecine Paris Descartes, Université Paris Descartes (Paris V), Sorbonne Paris Cité, Paris, France
3
École Doctorale en Infectiologie Tropicale, Franceville, Gabon
4
INSERM U970, Paris Cardiovascular Research Centre, Université Paris-Descartes, Sorbonne Paris Cité, Hôpital Européen Georges Pompidou, Paris, France
5
Service Des Maladies Infectieuses Et Tropicales, Centre Hospitalier Régional D’Orléans, La Source, France
Introduction High-risk (HR)-human papillomavirus (HPV) genotypes are responsible for 5.2% of all cancers worldwide, 2.2% of cancers in developed countries and 7.7% of all cancers in developing countries [1–3]. In sub-Saharan Africa, cervical cancer associated with persistent
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