Higher uric acid is associated with better discharge recovery and short-term outcome in stroke patients treated with thr
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ORIGINAL ARTICLE
Higher uric acid is associated with better discharge recovery and short-term outcome in stroke patients treated with thrombolysis Zhenjie Sun 1 & Jiying Feng 1 & Mingli He 1 & Min Wang 1 & Yongjin Zhang 1 & Na Wang 1 & Tingting Liu 1 & Guanghui Zhang 1 Received: 27 July 2020 / Accepted: 16 November 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Background Uric acid (UA) possesses antioxidant features and potential neuroprotective effects. However, conflicting results regarding the association between serum uric acid (SUA) levels and the prognosis of stroke have been obtained. We aimed to assess whether SUA is related to discharge recovery and short-term outcomes in patients who underwent thrombolysis therapy. Methods We recruited 393 consecutive patients who were diagnosed with acute ischaemic stroke (AIS) and treated with thrombolysis. The demographic information, including sex and age, was collected. Haematology tests, including SUA, fasting plasma glucose (FPG), and blood lipid parameters, were performed under fasting conditions the morning after admission. The modified Rankin Scale (mRS) was used to assess the functional outcome of patients at discharge and 3 months after onset. Results A negative correlation was observed between the levels of SUA and the National Institute of Health Stroke Scale (NIHSS) score at discharge (r = − 0.171, P = 0.003). Additionally, a positive correlation was observed between the levels of SUA and the difference between the baseline NIHSS and discharge NIHSS (r = 0.118, P = 0.032). The levels of SUA in the patients with good outcomes (353.76 ± 93.05) were higher than those in the patients with poor outcomes (301.99 ± 92.24; P = 0.015) at 3 months. The multivariate logistic regression analysis demonstrated that a higher SUA level (odds ratio 0.988, 95% confidence interval 0.985–0.991, P = 0.002) was an independent predictor of a good outcome at 3 months. Conclusion Higher SUA levels were associated with better discharge recovery and 3-month outcomes in patients with ischaemic stroke who received thrombolysis. Keywords Acute ischaemic stroke . Thrombolysis . Serum uric acid . Outcome
Uric acid (UA) is the metabolic end product of purines and is generated under the action of xanthine oxidase. The serum uric acid (SUA) concentration in humans is higher than that in most animals, which is suggestive of an evolutionary advantage associated with its antioxidant features and potential protective effects [1]. Recently, some studies have explored the relationship between SUA levels and stroke. However, conflicting results regarding the correlation between SUA levels and the incidence or prognosis of stroke have been obtained [2–5]. Zhenjie Sun and Jiying Feng contributed equally to this work. * Guanghui Zhang [email protected] 1
Department of Neurology, Lianyungang Hospital affiliated to Xuzhou Medical College, No. 182, Tongguan Road, Lianyungang, Jiangsu Province, People’s Republic of China
Some studies have provided evidence linking SUA to elevated risks o
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