Hippocampal Projections to the Ventral Striatum: From Spatial Memory to Motivated Behavior
Multiple regions of the hippocampal formation project to the ventral striatum, a central node in brain circuits that subserve aspects of motivation. These projections emphasize information flow from the ventral (temporal) pole of the hippocampus and inter
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Matthijs A.A. van der Meer, Rutsuko Ito, Carien S. Lansink, and Cyriel M.A. Pennartz
Abstract
Multiple regions of the hippocampal formation project to the ventral striatum, a central node in brain circuits that subserve aspects of motivation. These projections emphasize information flow from the ventral (temporal) pole of the hippocampus and interact with converging projections and neuromodulatory inputs upon arrival in the ventral striatum. Simultaneous neural recordings in the rat show that ventral striatal activity displays intricate timing relationships with the hippocampus, spanning multiple timescales and behavioral states, such as theta phase precession during reward approach and reactivation of placereward associations during sleep. Disconnection of the hippocampus and ventral striatum results in impairments in the use of spatial information for place preference, as well as in location-appropriate responding to reward-predictive cues. Together, these findings indicate that spatial and contextual information from the hippocampus shapes reward-predictive activity in the ventral striatum, which in turn contributes to the learning and expression of place-reward associations. Information processed by the hippocampus is dispersed to a number of structures. The anatomical properties of these projections form a basis for an exploration of how hippocampal processing ultimately contributes to behavior. In this chapter we discuss the anatomy and function of hippocampal projections to the ventral striatum, a heterogeneous brain structure that plays a central role in the motivational control of M.A.A. van der Meer (*) Department of Biology and Centre for Theoretical Neuroscience, University of Waterloo, 200 University Ave W, Waterloo, ON, Canada N2L 3G1 e-mail: [email protected] R. Ito Department of Psychology, University of Toronto at Scarborough, Toronto, ON, Canada C.S. Lansink • C.M.A. Pennartz Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands D. Derdikman and J.J. Knierim (eds.), Space, Time and Memory in the Hippocampal Formation, DOI 10.1007/978-3-7091-1292-2_18, # Springer-Verlag Wien 2014
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behavior (Berridge 2007; Nicola 2007; Humphries and Prescott 2010). The hippocampal input to the ventral striatum is therefore well placed to provide spatial and episodic information to aspects of motivation, such as learning from appetitive and aversive feedback and invigorating and directing ongoing behavior (Mogenson et al. 1980; Robbins and Everitt 1996; Pennartz et al. 2011; van der Meer and Redish 2011a). To be consistent with other chapters in this volume and to facilitate connections between anatomy, physiology, and behavior, we focus exclusively on studies in the rat. Most of these studies that included behavior have used spatial tasks, providing a rich domain for the study of different hippocampal-dependent aspects of memory (this volume; see also Mizumori 2007). However, for a more human-centered view with a different emphasis, s
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