Homocysteine Metabolism: From Basic Science to Clinical Medicine

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Developments in Cardiovascular Medicine Other books in the series M. LeWinter H. Suga and M.W. Watkins (eds.): Cardiac Energetics: From Emax to Pressure-volume Area. 1995 ISBN 0-7923-3721-2 R.J. Siegel (ed.): Ultrasound Angioplasty. 1995

ISBN 0-7923-3722-0

D.M. Yellon and G.J. Gross (eds.): Myocardial Protection and the Katp Channel. 1995 ISBN 0-7923-3791-3 A.V.G. Bruschke, J.H.c. Reiber, K.1. Lie and H.J.J. Wellens (eds.): Lipid Lowering Therapy and Progression of Coronary Atherosclerosis. 1996 ISBN 0-7923-3807-3 A.S.A. Abd-Elfattah and A.S. Wechsler (eds.) Purines and Myocardial Protection. 1995 ISBN 0-7923-3831-6 M. Morad, S. Ebashi, W. Trautwein and Y. Kurachi (eds.): Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. 1996 ISBN 0-7923-3913-4 A.M. Oto (ed.): Practice and Progress in Cardiac Pacing and Electrophysiology. 1996 ISBN 0-7923-3950-9 W.H. Birkenhager (ed.): Practical Management of Hypertension. Second Edition. 1996 ISBN 0-7923-3952-5 ).c. Chatham, ).R. Forder and J.H. McNeill (eds.): The Heart In Diabetes. 1996 ISBN 0-7923-4052-3 M. Kroll, M. Lehmann (eds.): Implantable Cardioverter Defibrillator Therapy: The Engineering-Clinical Interface. 1996 ISBN 0-7923-4300-X Lloyd Klein (ed.): Coronary Stenosis Morphology: Analysis and Implication. 1996 ISBN 0-7923-9867-X Johan H.C. Reilber, Ernst E. Van der Wall (eds.): Cardiovascular Imaging. 1996 ISBN 0-7923-4109-0 A.-M. Salmasi, A. Strano (eds.): Angiology in Practice.

ISBN 0-7923-4143-0

Julio E. Perez, Roberto M. Lang (eds.): Echocardiography and CardiovascularFunction: Tools for the Next Decade. 1996 ISBN 0-7923-9884-X Keith 1. March (ed.): Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications. 1997 ISBN 0-7923-9859-9 Anne A. Knowlton (ed.): Heat Shock Proteins and the Cardivoascular System. 1997 ISBN 0-7923-9910-2 Richard C. Becker (ed.): The Textbook of Coronary Thrombosis and Thrombolysis. 1997 ISBN 0-7923-9923-4 Robert M. Mentzer, Jr., Masafumi Kitakaze, James M. Downey, Masatsugu Hori ISBN 0-7923-9954-4 (eds.): Adenosine, Cardioprotection and its Clinical Application Ian Graham, Helga Refsum, Irwin H. Rosenberg, Per Magne Ueland (eds.): Homocysteine Metabolism: From Basic Science to Clincal Medicine ISBN 0-7923-9983-8

HOMOCYSTEINE METABOLISM: FROM BASIC SCIENCE TO CLINICAL MEDICINE Editors

lan Graham, MD THE ADELAIDE HOSPITAL TRINITY COLLEGE DUBUN IRELANO

Helga Refsum, MD UNIVERSITY OF BERGEN DEPARTMENT OF CUNlCAL BIOLOGY BERGEN NORWAY

lrwin H. Rosenberg, MD JEAN MAYER USDA HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY BOSTON,MA USA

Per Magne Ueland, MD UNIVERSITY OF BERGEN DEPARTMENT OF CUNICAL BIOLOGY BERGEN NORWAY

Scientific Editor:

JiU M. Shuman, MS, RD, ELS TUFTS UNIVERSITY SCHOOL OF NUTRITION SCIENCE ANO POUCY MEDFORD,MA USA

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Springer Science+Business Media, LLC

ISBN 978-1-4613-7645-3 ISBN 978-1-4615-5771-5 (eBook) DOI 10.1007/978-1-4615-5771-5 Library of Congress Cataloging-in-Publication Data Homocysteine metabolism: from basic science to