How does intraarticular dexmedetomidine injection effect articular cartilage and synovium? An animal study
- PDF / 7,852,698 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 63 Downloads / 172 Views
RESEARCH ARTICLE
Open Access
How does intraarticular dexmedetomidine injection effect articular cartilage and synovium? An animal study Başak Akça1* , Aysun Ankay Yılbaş1, Filiz Üzümcügil1, Berkem Büyükakkuş1, Elham Bahador Zırh2, Dilara Zeybek2 and Fatma Sarıcaoğlu1
Abstract Background: Intraarticular injections are widely used to provide pain relief after arthroscopic procedures and minimize the use of opioids. Dexmedetomidine has been proven to potentiate pain relief and postpone the demand for the first analgesic drug when it is used intraarticularly following arthroscopic knee procedures. However, the effects of dexmedetomidine on articular structures have not yet been evaluated. Our aim was to determine the effects of intraarticular dexmedetomidine injection on articular structures such as cartilage and synovium. Design: Animal study. Methods: Twenty adult rats (Sprague-Dawley) were enrolled in the study. Following appropriate aseptic and anesthetic conditions, dexmedetomidine (100 mcg/ml) (0.25 ml) was injected into the right knee joint (the study group) and normal saline solution (0.25 ml) into the left knee joint (the control group) of the rats. Four rats were sacrificed from each group on days 1, 2, 7, 14, and 21, and knee joint samples were obtained. Histologists evaluated the articular and periarticular regions and the synovium using histological sections, and a five-point scale was used to grade the inflammatory changes in a blinded manner. Results: The groups were found to be similar in terms of median congestion scores, edema and inflammation scores, subintimal fibrosis, neutrophil activation and cartilage structure at each of the time intervals. Conclusion: In our placebo-controlled, in vivo trial, the intraarticular use of dexmedetomidine seemed to be safe with respect to the studied histopathological parameters. However, complementary studies investigating the histopathological effects, analgesic dosage and adverse effects of dexmedetomidine on damaged articular structure models are needed. Keywords: Dexmedetomidine, Injection, Intraarticular, Rats, Local anesthetics, Joint, Knee
* Correspondence: [email protected] This trial was presented orally in ESRA Congress 2017, Lugano,Switzerland 1 Department of Anesthesiology and Reanimation, Hacettepe University School of Medicine, Sıhhiye, 06230 Ankara, Turkey Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence an
Data Loading...
