Diverse Roles of Integrin Receptors in Articular Cartilage
Integrins belong to an evolutionary conserved family of adhesion molecules with important biological functions throughout the animal kingdom. They are heterodimeric glycoproteins involved in cell-cell and cell-matrix adhesion and communication. Physiologi
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Anatomy Embryology and Cell Biology
Editors F.F. Beck, Melbourne . F. Clascá, Madrid M. Frotscher, Freiburg . D.E. Haines, Jackson N. Hirokawa, Tokyo . Z. Kmiec, Gdansk H.-W. Korf, Frankfurt . E. Marani, Enschede R. Putz, München . Y. Sano, Kyoto T.H. Schiebler, Würzburg J.-P. Timmermans, Antwerpen
M. Shakibaei, C. Csaki and A. Mobasheri
Diverse Roles of Integrin Receptors in Articular Cartilage With 36 Figures
Mehdi Shakibaei Constanze Csaki Institute of Anatomy Musculoskeletal Research Group Ludwig-Maximilian-University Munich Pettenkoferstrasse 80336 Munich Germany e-mail: [email protected] Ali Mobasheri Division of Comparative Veterinary Medicine School of Veterinary Medicine and Science University of Nottingham Sutton Bonington Campus Loughborough Leicestershire LE12 5RD UK
ISSN 0301-5556 ISBN 978-3-540-78770-9
e-ISBN 978-3-540-78771-6
Library of Congress Control Number: 2008923175 © 2008 Springer-Verlag Berlin Heidelberg This work is subject ot copyright. All rights are reserved, whether the whold or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, roadcasting reporduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt form the relevant protecttive laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com
List of Contents
1 1.1 1.2 1.3 1.4
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Integrins: Multifunctional Adhesion Molecules . . . . . . . . . . . . . . . . . . . . Integrin Structure–Function Relationships . . . . . . . . . . . . . . . . . . . . . . . . Structure of Integrins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF Domains in β1-Integrins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 4 6 7 10
2 2.1 2.1.1
Integrins in Articular Cartilage. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Monolayer Cultures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Expression Pattern and Changes of Integrins on Chondrocytes in Monolayer Culture . . . . . . . . . . . . . . . . . . . . . . . . . . . Integrin Expression and Collagen Type II are Implicated
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