HOXC9 overexpression is associated with gastric cancer progression and a prognostic marker for poor survival in gastric
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ORIGINAL ARTICLE
HOXC9 overexpression is associated with gastric cancer progression and a prognostic marker for poor survival in gastric cancer patients Xue‑Feng Zhao1 · Yu‑Shen Yang1 · Young Kyu Park2 Received: 26 May 2020 / Accepted: 10 August 2020 © Japan Society of Clinical Oncology 2020
Abstract Background As a member of the homeobox family, HOXC9 is overexpressed in several malignant tumors and may be regarded as a biomarker for prognostic evaluation. However, the expression pattern and prognostic significance of HOXC9 in gastric cancer have not been detailedly studied. Methods HOXC9 mRNA expression difference in normal tissues and gastric cancer tissues were investigated using RT-PCR, and immunohistochemistry was used to analyze HOXC9 protein expression in precancerous lesions and gastric cancer at different stages, and its clinicopathological characteristics and survival were statistically tested. Results Compared to the normal gastric mucosa tissues, the expression levels of HOXC9 mRNA in the human gastric cancer tissues were significantly higher. HOXC9 protein levels of gastric cancer were obviously higher than that in other noncancerous tissues (P
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