HR-HPV viral load quality detection provide more accurate prediction for residual lesions after treatment: a prospective
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ORIGINAL PAPER
HR‑HPV viral load quality detection provide more accurate prediction for residual lesions after treatment: a prospective cohort study in patients with high‑grade squamous lesions or worse Lihua Chen2 · Binhua Dong1 · Qiaoyu Zhang2 · Xiaodan Mao1 · Wenyu Lin1 · Guanyu Ruan1 · Yafang Kang1 · Pengming Sun1,2 Received: 19 February 2020 / Accepted: 11 March 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The relationship between high-risk-human-papillomavirus (HR-HPV) viral loads and residual/recurrence lesion is uncertain. This study aimed to evaluate the clinical value of HR-HPV viral loads to predict the residual/recurrence lesions among women with high-grade squamous lesions or worse (≥ HSIL) after surgery. Finally, 301 women who underwent primary screening of cervical cancer using polymerase-chain-reaction-(PCR)-reverse-dot-blot-(RDB) human papillomavirus (HPV) genotyping and cytology assays were enrolled. They received surgery and took HR-HPV viral loads with a BioPerfectus Multiplex Real-Time PCR assay. Colposcopy biopsies were performed in patients with HPV-16/18(+) and/or TCT ≥ ASCUS with HR-HPV(+). The risk of HR-HPV viral loads and potentials factors for residual/recurrence lesions were analyzed and the optimal cut-off values of HR-HPV viral loads were calculated. The significant differences were found in residual/recurrence lesions among patients with different ages, margin status, cytology and HR-HPV at 6 months (all P
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