Human Neural Stem Cells From Generation to Differentiation and Appli
This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to gener
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Leonora Buzanska Editor
Human Neural Stem Cells
From Generation to Differentiation and Application
Results and Problems in Cell Differentiation
Volume 66
Series editors Jacek Z. Kubiak, Rennes CX, France Malgorzata Kloc, Houston, TX, USA
More information about this series at http://www.springer.com/series/400
Leonora Buzanska Editor
Human Neural Stem Cells From Generation to Differentiation and Application
Editor Leonora Buzanska Stem Cell Bioengineering Unit Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw, Poland
ISSN 0080-1844 ISSN 1861-0412 (electronic) Results and Problems in Cell Differentiation ISBN 978-3-319-93484-6 ISBN 978-3-319-93485-3 (eBook) https://doi.org/10.1007/978-3-319-93485-3 Library of Congress Control Number: 2018955150 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
Part I 1
2
Derivation and/or Generation of Human Neural Stem Cells
Derivation of Neural Stem Cells from the Developing and Adult Human Brain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Claire M. Kelly and Maeve A. Caldwell 1.1 Foetal Neural Stem Cells (NSCs) . . . . . . . . . . . . . . . . . . . . . . . 1.1.1 Mitogens Used for In Vitro Proliferation of hNSCs . . . 1.1.2 Longer-Term Growth of hNSCs . . . . . . . . . . . . . . . . . 1.1.3 Regional Differences . . . . . . . . . . . . . . . . . . . . . . . . . 1.2 Adult Neural Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.3 Good Manufacturing Practice Production . . . . . . . . . . . . . . . . . 1.4 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Refe
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