Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer
Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health eff
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n Papillomavirus (HPV)-Associated Oropharyngeal Cancer
Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer
Daniel L. Miller · M. Sharon Stack Editors
Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer
13
Editors Daniel L. Miller School of Medicine University of Missouri Columbia, MO USA
M. Sharon Stack Department of Chemistry and Biochemistry, Harper Cancer Research Institute University of Notre Dame South Bend, IN USA
ISBN 978-3-319-21099-5 ISBN 978-3-319-21100-8 (eBook) DOI 10.1007/978-3-319-21100-8 Library of Congress Control Number: 2015943436 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Contents
1
Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Susanne M. Gollin
2
Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Teresa A. Anderson and Aaron C. Ermel
3
Racial Disparities in Oropharyngeal Cancer. . . . . . . . . . . . . . . . . . . . 43 Lucia Pirisi, Swati Tomar and Saundra H. Glover
4
HPV Virology: Cellular Targets of HPV Oncogenes and Transformation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Eric A. Smith, Marie C. Matrka and Susanne I. Wells
5
Papillomavirus Replication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 Sara P. Culleton, Elliot J. Androphy and Sriramana Kanginakudru
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MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC). . . . . . . . . . . . . . . . . . . . . . . . . . 133 Daniel Lee Miller and M. Sharon Stack
7
Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignanc
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