Human Papillomavirus (HPV)-Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma-Like Feat
- PDF / 3,886,218 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 23 Downloads / 188 Views
CASE REPORTS
Human Papillomavirus (HPV)‑Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma‑Like Features: Report of a Case Christina K. Hodgson1 · Rodrigo Bayon2 · Chris S. Jensen1 · Robert A. Robinson1 · Anand Rajan K.D.1 Received: 22 July 2020 / Accepted: 6 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract We describe the heretofore unreported case of an HPV-related carcinoma of the palatine tonsil with distinct areas of squamous cell- and adenoid cystic carcinoma-like differentiation in a 54-year old patient. The morphological, immunophenotypic and molecular findings of the tumor are illustrated. We discuss the parallels between the tumor and HPV-related multiphenotypic sinonasal carcinoma (HMSC) which is well-known to exhibit adenoid cystic carcinoma-like features. A review of the literature of high-risk HPV-associated non-squamous carcinomas of the oropharynx is presented. Keywords HPV-related · Adenoid-cystic like features · HPV mRNA in situ hybridization · Multiphenotypic · Biphenotypic carcinoma · HMSC · HPV16
Introduction The morphologic spectrum and clinical characteristics of human papillomavirus (HPV) associated nonkeratinizing squamous cell carcinoma of the oropharynx are now well understood. In the initial decade(s), pathologists and researchers elucidated the essential features of this tumor [1, 2] and its distinction from typical keratinizing squamous cell carcinoma of the oral cavity. A strong association with high-risk HPV type 16 [3, 4] was demonstrated, followed by a search (still ongoing) for other upper aerodigestive tract tumors that showed an association with transcriptionally active HPV infection. Though HPV-associated tumors of the oropharynx with other morphologies have been described these have likewise been predominantly either variants of squamous cell carcinoma [1, 5] or rare entities such as ciliated adenocarcinoma with only a few reported instances [6, 7]. Among these, the HPV-related multiphenotypic sinonasal * Anand Rajan K.D. anand‑[email protected] 1
Department of Pathology, University of Iowa Hospitals and Clinics, 5239D 200 Hawkins Drive, Iowa City, IA 52242, USA
Department of Otolaryngology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
2
carcinoma (HMSC) is the most recent well- characterized neoplasm [8] with consistent if variegated non-squamous differentiation, most notably including adenoid cystic carcinoma-like differentiation [9, 10]. Here we describe a hitherto undescribed case of an HPV type 16-related primary tumor with biphenotypic squamous-and adenoid cystic carcinoma (AdCC) differentiation involving the palatine tonsillar oropharynx. We review the occurrence of HPV-associated adenocarcinoma involving the oropharynx in the literature and summarize parallels between the present case and HMSC.
Case Report The patient is a 54-year old man who initially presented with a history of a left-sided neck mass for 4 months. Physical examination per
Data Loading...
