Hyperbaric Oxygenation Therapy Molecular Mechanisms and Clinical App
This book focuses on hyperbaric oxygenation (HBO) therapy from the molecular biology perspective and its clinical applications, including molecular mechanisms of HBO’s positive effect on cellular function in hypoxic tissues.HBO is a therapeutic tool that
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Hyperbaric Oxygenation Therapy
Nariyoshi Shinomiya • Yasufumi Asai Editors
Hyperbaric Oxygenation Therapy Molecular Mechanisms and Clinical Applications
Editors Nariyoshi Shinomiya Department of Integrative Physiology and Bio-Nano Medicine National Defense Medical College Tokorozawa Saitama Japan
Yasufumi Asai Hakodate Shintoshi Hospital Hakodate Hokkaido Japan
ISBN 978-981-13-7835-5 ISBN 978-981-13-7836-2 (eBook) https://doi.org/10.1007/978-981-13-7836-2 © Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Hyperbaric oxygen (HBO) therapy is a well-known traditional treatment method for patients with tissue hypoxia. It improves tissue oxygen levels and brings increased capacity of wound healing/tissue remodeling. It also revitalizes the cell activity to increase survival and modulates anti-inflammatory/immunological function of immune cells, which leads to the recovery of hosts from severe infection. The application of HBO therapy has a wide range of choices including carbon monoxide poisoning, infectious diseases refractory to regular antibiotics treatment such as necrotizing soft tissue infections, gas gangrene and osteomyelitis, traumatic ischemia, crush injury, diabetic foot, and so on. It can also be applied for curing divingrelated disorders such as gas embolism and decompression illness; in such cases, HBO is used as a specialized method of treatment named recompression therapy. However, HBO therapy is not a dream-like therapy but a complementary one to support other treatment methods or express effects in cooperation with other treatment options. Then why does HBO bring successful outcome in p
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