Principles of Osteoimmunology Molecular Mechanisms and Clinical Appl
This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is pr
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Principles of Osteoimmunology Molecular Mechanisms and Clinical Applications Second Edition
Principles of Osteoimmunology
Peter Pietschmann Editor
Principles of Osteoimmunology Molecular Mechanisms and Clinical Applications Second Edition
Editor Peter Pietschmann Department of Pathophysiology and Allergy Research Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria
ISBN 978-3-319-34236-8 ISBN 978-3-319-34238-2 DOI 10.1007/978-3-319-34238-2
(eBook)
Library of Congress Control Number: 2016949412 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Osteoimmunology is a rapidly developing research field on the crosstalk between bone and the immune system. Examples of such immune-bone interactions are pathogenic mechanisms of bone diseases that are caused by or related to altered immune reactions. The English term “osteoimmunology” was first used in 2000 by Arron and Choi in a comment in Nature (430: 535). Nevertheless, the concept that osteoclasts, multinucleated bone-resorbing cells, develop from the monocytemacrophage lineage dates back to the 1920s. In the 1980s, proinflammatory cytokines such as interleukin-1 or TNF-alpha were shown to stimulate bone degradation. The discovery of the RANK/RANKL/osteoprotegerin system and the development of antibody-based targeted therapies for osteoporosis and other bone diseases have significantly increased the momentum of osteoimmunology. The purpose of this book is to give an introduction to the field of osteoimmunology to scientists and clinicians working in immunology, pathophysiology and osteology. The book is organized into 12 chapters. The first chapters give an introduction to cell and molecular biology of bone and the immune system, including methodological issues su
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