Hypoglycemic Activity of Isolated Compounds from Gomphrena celosioides Mart
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Pharmaceutical Chemistry Journal, Vol. 54, No. 5, August, 2020 (Russian Original Vol. 54, No. 5, May, 2020)
HYPOGLYCEMIC ACTIVITY OF ISOLATED COMPOUNDS FROM Gomphrena celosioides MART Loi Vu Duc,1,* Duong Le Hong,1 and Giang Dinh Hoang1 Original article submitted February 9, 2020. Five compounds (1 -– 5) were isolated from the leaves of Gomphrena celosioides Mart species harvested in Nam Dinh province and studied by chromatographic method. These compounds were identified as cleomiscosin A (1), dictyoceratin- C (2), ilimaquinone (3), bruceolline F (4), and neodactyloquinone (5). Their structures were elucidated by spectroscopic techniques including mass spectrometry (MS) and nuclear magnetic resonance (NMR). These compounds were isolated from the leaves of G. celosioides for the first time. All compounds were evaluated for their hypoglycemic activity in PTP1B inhibition and glucose uptake into 3T3-L1 adipocytes enhancement models. Results showed that compound 5 produced maximum effect with PTP1B inhibitory activity of 80.39 ± 6.88%, IC50 = 42.78 ± 2.86 mM, as well as the strongest ability to enhance glucose uptake in 3T3-L1 adipocytes. Keywords: Gomphrena celosioides Mart.; G. celosioides; cleomiscosin A; dictyoceratin-C; ilimaquinone; bruceolline F; neodactyloquinone.
portant properties, in particular antioxidant [5], anti-inflammatory and antiviral [6], antibacterial and immunomodulating [7]. These findings supported the use of this plant in folk medicine to treat gastrointestinal, respiratory or infectious diseases. In Vietnam, people advice to use G. celosioides (bachelor’s button) as a precious medicine to cure diabetes. However, studies on chemical composition and biological effects of this plant in Vietnam and over the world are still limited. Therefore, in order to provide more data on bachelor’s button, as well as to help guide the use of this medicinal herbs more effectively, this study provides information on the hypoglycemic effects and the chemical composition of n-hexane fraction from G. celosioides leaves extract.
1. INTRODUCTION The Gomphrena genus (Amaranthaceae family) contains more than 130 species, including native species in Central Malesia to Oceania, tropical and subtropical Americas, and introduced species in Africa, Central Asia and East Asia countries. In Vietnam, plants of the Gomphrena genus grow wild in many regions with hot dry climate, seashore, roadsides, railways, especially in the Southwest and Middle regions. Gomphrena celosioides Mart. is a member of the Amaranthaceae family. Bamba, et al. [1] proved that there is no risk of intoxication with ethanol extract of G. celosioides (EEGC < 5000 mg/kg mice weight), but at doses ³ 5000 mg/kg it causes hepatocellular hypotension and liver dysfunction [1]. Olalele, et al. [2] reported that EEGC (200 mg/kg) had an anti-inflammatory effect equivalent to sodium diclofenac (10 mg/kg) on carrageenan-induced inflammation in rats [2]. Meite, et al. [3] evaluated the antioxidant effect of EEGC using serum thiobarbituric acid reduction activity.
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