Hypothetical mechanism of light action on nitric oxide physiological effects
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ORIGINAL ARTICLE
Hypothetical mechanism of light action on nitric oxide physiological effects Titov Vladimir 1,2,3 & Osipov Anatoly 1 & Ibragimova Larisa 1 & Petrov Vladimir 1 & Dolgorukova Anna 2 & Oleshkevich Аnna 3 Received: 31 July 2020 / Accepted: 21 October 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Nitric oxide is a universal cellular mediator. It is involved in many physiological processes, including those induced by light. The disability for complete analysis of the nitric oxide metabolites in tissues prevents the exact understanding of the role of NO in a particular process. The sensitivity and selectivity of an enzymatic sensor developed in our lab is based on the detection of all NO groups that carry a positive charge or acquire it in the chemical processes. Using this sensor, we have shown that dinitrosyl iron complexes (DNIC), being principal nitric oxide donors in most of living tissues, undergo transformations under light irradiation in the wavelength range of 400–700 nm. These changes are not associated with nitric oxide release to the environment. But a nitrosyl iron complex without thiol ligands (Fe(NO)n) is produced. Moreover, in the moment of the complex reorganization, the chemical bond between the NO group and other components apparently weakens and, in the presence of a substance possessing chemical affinity to the NO group, the latter acquires the ability of transition from the complex to this substance. Therefore, the efficiency of NO donors first of all depends on the existence of the NO target and its status including that under the action of light. The activation of a donor compound by light can facilitate the transfer of NO to the target. Transfer of NO from the donor to the target occurs without releasing NO, or with a minimum time of its stay in the unbound state. Keywords Nitric oxide (NO) . Dinitrosyl iron complex . Light . Nitrite
Introduction * Titov Vladimir [email protected] Osipov Anatoly [email protected] Ibragimova Larisa [email protected] Petrov Vladimir [email protected] Dolgorukova Anna [email protected] Oleshkevich Аnna [email protected] 1
FSBEI HE Russian National Research N.I. Pirogov Medical University, Moscow, Russia
2
FSC Russian National Research and Technological Poultry Farming Institute, RAS, Moscow region, Russia
3
Moscow State K.I. Skryabin Academy of Veterinary Medicine and Biotechnology, Moscow, Russia
Nitric oxide (NO) is a universal cell mediator of many physiological functions. It is considered that synthesized NO molecules are included in so-called NO donor compounds mediating the interaction of NO with physiological targets [1]. NO is known to regulate the tonus of smooth muscles and platelet aggregation via activation of guanylate cyclase [2, 3] and to regulate tissue differentiation and apoptosis via its effects on caspase [4, 5]. NO also regulates the expression of certain genes [6]. There exist data that some physiological light effects are also associated with nitric oxide [7, 8]. Instances
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