Nitric Oxide

Nitric oxide (NO) has been discovered to play a fundamental role in a number of biological phenomena. This book describes various aspects of nitric oxide biology, physiology and pharmacology. It is divided into three sections. The first part deals with th

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Springer-Verlag Berlin Heidelberg GmbH

Nitric Oxide Contributors l-L. Balligand, T.R. Billiar, C. Bogdan, B. Brune, H. Bult, V. Burkart, R. Busse, A. Costa, T.M. Dawson, V.L. Dawson, VJ. Dzau, M.G. Espey, K. Falke, M. Feelisch , 1. Fleming, U. Forstermann, A. Friebe, 1 Fukuto, 1 Garthwaite, H. Gerlach, S. Ghosh, M.B. Grisham, A.B. Grossman, E. Hackenthal, D. Keh, M.M, Kockx, D. Koesling, G. Kojda, H. Kolb, P.A. MacCarthy, W. Martin, K.E. Matthys, L. McNaughton, K.M. Miranda, lB. Mitchell, S. Moncada, P. Navarra, 1 Parkinson, A. Radomski, M.W. Radomski, D. Rees, K. Sandau, M. Sasaki , G. Sawicki, H.H.H.W. Schmidt, A.M. Shah, DJ. Stuehr, P. Vallance, H.E. von der Leyen, A. von Knethen, E.R. Werner, D.A. Wink, R. Zamora

Editor

B. Mayer

,

Springer

Universit ăts-Professor Dr. B ERND M AYER Department of Pharmacology and Toxicology Karl-Franzens-University of Graz Unive rsi tă ts platz 2 8010 G raz AUSTRIA e-mail: [email protected]

With 73 Figures and 34 Tables ISBN 978-3-642-63026-2 Library of Co ngress Cata loging-in-Publication Data Nitric oxide / Co ntributors, J-L. BalIigand . . . [et al.]: editor, B. Mayer. p. cm, - (Ha ndbook of experimental pharm acology; v, 143) Includes bibliographical references and inde x.

ISBN 978-3-642-63026-2 ISBN 978-3-642-57077-3 (eBook) DOI 10.1007/978-3-642-57077-3

1. Nitric oxide- Physiological effect. 2. Nitric oxide- Pathophysiology. 1. Mayer, B. (Bernd), I959II. BalIigand ,J.- L. (Jean-L uc) III . Series. QP535.NI N54I7 2000 99-087335 572'.54 - dc2I

This work is subject to copyright. AII rights are reserved , whethe r the whole or part of the materi al is concern ed , specificalIy the rights of translation, reprintin g re-use of ilIustrati ons, recitation, bro adcasting, reproduction on microfilms or in any other way, and storage in dat a banks, Dupl ication of this publ ication or part s the reof is permitted only under the provisions of the German Copyright Law of Septemb er 9,19 65, in its current version, and permission for use must always be ob tain ed from Springer-Verlag. Violations are liable for Prosecution under the German Copyright Law. Springer-Ver lag is a comp any in the Bertelsmann Springer publishing gro up © Springer-Verlag Berlin Heidelberg 2000 Originally published by Springer-Verlag Berlin Heidelberg New York in 2000 Softcover reprint of the hardcover l st edition 2000 The use of general descriptive names, registered names, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application cont ained in this boo k. In every individual case the user must check such informa tion by consulting the relevant lite rature. Cover design: design & prod uction GmbH, Heidelberg Typesetting: Rest-set Typesett er Ltd., Hong Kon g SPIN: 10673334

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Preface

It must be hard, nowad