Hypoxia and Cancer Metastasis
The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular c
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Daniele M. Gilkes Editor
Hypoxia and Cancer Metastasis
Advances in Experimental Medicine and Biology Volume 1136
Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Daniele M. Gilkes Editor
Hypoxia and Cancer Metastasis
Editor Daniele M. Gilkes Breast and Ovarian Cancer Program, Department of Oncology The Johns Hopkins School of Medicine Baltimore, MD, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-12733-6 ISBN 978-3-030-12734-3 (eBook) https://doi.org/10.1007/978-3-030-12734-3 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
I am pleased to introduce the book entitled Hypoxia and Cancer Metastasis in the Advances in Experimental Medicine and Biology series. The latest books on hypoxia and cancer, edited by Celeste Simon in 2010 and Giovanni Melillo in 2014, offered an excellent overview for scientists interested in the role of hypoxia in cancer biology. The current book aims to provide an update with a specific focus on hypoxia and metastasis. I am thankful that each contributor wholeheartedly welcomed the invitation to contribute chapters to provide a comprehensive (to-date) understanding of the role of hypoxia in metastasis. Each of the contributors has spent their
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