Metastasis: A Major Driver of Cancer Pathogenesis
Cancer is a multifactorial condition that originates from genomic alterations in the cells, which confer them the ability to evade various cellular regulations and proliferate incessantly. Furthermore, the accumulation of these mutations confers metastati
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rug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models
Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models
Hardeep Singh Tuli Editor
Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models
Editor Hardeep Singh Tuli Department of Biotechnology Maharishi Markandeshwar (Deemed to be University), Mullana Ambala, Haryana, India
ISBN 978-981-15-7585-3 ISBN 978-981-15-7586-0 https://doi.org/10.1007/978-981-15-7586-0
(eBook)
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Dedicated to My Beloved Parents
Preface
Cancer is a major cause of death worldwide and is known to be the biggest killer in the twenty-first century. It has been ranked second in mortality rate following cardiovascular diseases in most of the countries. Every year, the number of people being diagnosed with cancer is increasing very fast. Due to the lack of significant improvement in diagnosis, treatment, and prevention, cancer has or will soon become the number one killer in most parts of the world. Induced side effects and acquired resistance against anticancer drugs create the hassle for the treatment of cancer and the enthusiasm for the development of new approaches. Further, application of safe compounds with strong anticancer properties may open new avenues in the fight against this devastating disorder. Therefore, different antitumor mechanisms of drugs, that is, cell cycle arrest, apoptosis induction, antioxidant, anti-inflammatory, antiproliferative, antiangioge
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