Signal Transduction in Cancer Metastasis
The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this l
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Cancer Metastasis – Biology and Treatment VOLUME 15 Series Editors Richard J. Ablin, Ph.D., University of Arizona, College of Medicine and The Arizona Cancer Center, AZ, U.S.A. Wen G. Jiang, M.D., Wales College of Medicine, Cardiff University, Cardiff, U.K. Advisory Editorial Board Harold F. Dvorak, M.D. Phil Gold, M.D., Ph.D. Danny Welch, Ph.D. Hiroshi Kobayashi, M.D., Ph.D. Robert E. Mansel, M.S., FRCS. Klaus Pantel, Ph.D. Recent Volumes in this Series Volume 7: DNA Methylation, Epigenetics and Metastasis Editor: Manel Esteller ISBN 978-1-4020-3641-8 Volume 8: Cell Motility in Cancer Invasion and Metastasis Editor: Alan Wells ISBN 978-1-4020-4008-3 Volume 9: Cell Adhesion and Cytoskeletal Molecules in Metastasis Editors: Anne E. Cress and Raymond B. Nagle ISBN 978-1-4020-5128-X Volume 10: Metastasis of Prostate Cancer Editors: Richard J. Ablin and Malcolm D. Mason ISBN 978-1-4020-5846-2 Volume 11: Metastasis of Breast Cancer Editors: Robert E. Mansel, Oystein Fodstad and Wen G. Jiang ISBN 978-1-4020-5866-7 Volume 12: Bone Metastases: A Translational and Clinical Approach Editors: Dimitrios Kardamakis, Vassilios Vassiliou and Edward Chow ISBN 978-1-4020-9818-5 Volume 13: Lymphangiogenesis in Cancer Metastasis Editors: Steven A. Stacker and Marc G. Achen ISBN 978-90-481-2246-2 Volume 14: Metastasis of Colorectal Cancer Editors: Nicole Beauchemin and Jacques Huot ISBN 978-90-481-8832-1 Volume 15: Signal Transduction in Cancer Metastasis Editors: Wen-Sheng Wu and Chi-Tan Hu ISBN 978-90-481-9521-3
Signal Transduction in Cancer Metastasis Edited by
Wen-Sheng Wu Associated Professor, Institute of Medical Biotechnology, College of Medicine, Tzu-Chi University, Hualien, Taiwan and
Chi-Tan Hu Associated Professor, Research Center for Hepatology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan
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Editors Dr. Wen-Sheng Wu Institute of Medical Biotechnology College of Medicine Tzu-Chi University Chung-Yang Rd, Sec 3 701 970 Hualien Taiwan R.O.C. [email protected]
Dr. Chi-Tan Hu Research Center for Hepatology Department of Medicine Buddhist Tzu-Chi General Hospital Chung-Yang Rd, Sec 3 707 907 Hualien Taiwan R.O.C. [email protected]
ISSN 1568-2102 ISBN 978-90-481-9521-3 e-ISBN 978-90-481-9522-0 DOI 10.1007/978-90-481-9522-0 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010936099 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Cancer remains to be one of the most devastating diseases world wide since long ago. The poor prognosis of cancer is largely due to metasta
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