Identification of oral cancer in OCT images based on an optical attenuation model
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ORIGINAL ARTICLE
Identification of oral cancer in OCT images based on an optical attenuation model Zihan Yang 1 & Jianwei Shang 2 & Chenlu Liu 3 & Jun Zhang 4 & Yanmei Liang 1 Received: 15 December 2019 / Accepted: 16 April 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Surgery is still the first choice to treat oral cancer, where it is important to detect surgical margins in order to reduce cancer recurrence and maintain oral-maxillofacial function simultaneously. As a non-invasive and in situ imaging technique, optical coherence tomography (OCT) can obtain images close to the resolution of histopathology, which makes it have great potential in intraoperative diagnosis. However, it is not enough to find surgical margins accurately just observing OCT images directly and qualitatively. The purpose of this study is to identify oral cancer in OCT images by investigating the quantitative difference of cancer and non-cancer tissue. Based on an available optical attenuation model and the axial confocal PSF of a home-made swept source OCT system, by using fresh ex vivo human oral tissues from 14 patients of oral squamous cell carcinoma (OSCC) as the samples, diagnosis with sensitivity (97.88%) and specificity (83.77%) was achieved at the attenuation threshold of 4.7 mm−1, and the accuracy of identification reached 91.15% in our study. Our preliminary results demonstrated that the oral cancer resection will be guided accurately and the clinical application of OCT will be further promoted by deeply mining the information hidden in OCT images. Keywords Optical coherence tomography . Oral squamous cell carcinoma (OSCC) . Optical attenuation model . Quantitative analysis
Introduction Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the oral cavity, and the 5-year survival rate of patients is still less than 50% (the mortality rate largely increases from ~ 17 to ~ 62% when the oral cancer progresses from local stage to distant stage) [1, 2]. The evidence suggests that the gross total resection (GTR) is the most important
* Yanmei Liang [email protected] 1
Institute of Modern Optics, Nankai University, 38 Tongyan Road, Tianjin 300350, China
2
Department of Oral Pathology, Tianjin Stomatological Hospital; Hospital of Stomatology, Nankai University, Tianjin 300041, China
3
Department of Oral Medicine, Tianjin Stomatological Hospital; Hospital of Stomatology, Nankai University, Tianjin 300041, China
4
Department of Oral-Maxillofacial Surgery, Tianjin Stomatological Hospital; Hospital of Stomatology, Nankai University, Tianjin 300041, China
factor for delaying tumor recurrence and prolonging survival [3, 4]. In clinical practice, the GTR of oral cancer is usually determined by palpation of experienced clinicians. Due to the infiltration of cancer cells, if not being completely removed, it will lead to the recurrence of cancer. On the other hand, subjective enlarged resection will increase the patient’s recovery process. Accurate diagnoses of oral lesions still need t
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