Imaging Biomarkers Development and Clinical Integration
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imagin
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Imaging Biomarkers
Luis Martí-Bonmatí Angel Alberich-Bayarri Editors
Imaging Biomarkers Development and Clinical Integration
Editors Luis Martí-Bonmatí La Fe University and Polithecnic Hospital University of Valencia Valencia Spain
Angel Alberich-Bayarri La Fe University and Polithecnic Hospital University of Valencia Valencia Spain
ISBN 978-3-319-43502-2 ISBN 978-3-319-43504-6 DOI 10.1007/978-3-319-43504-6
(eBook)
Library of Congress Control Number: 2016957713 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland The registered company is Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
This book started so many years ago. On those times, most researchers on medical imaging were involved in how to obtain the best images to achieve accurate diagnosis in clinical medicine. Detecting lesions and knowing the nature of what was found and how these findings impact treatment were the hallmarks of radiology for years. Our contribution was to initiate quantitative approaches to improve the way radiology was performed. In some way, measurements were not usual in the radiology departments, and, even, they were considered an inappropriate way to describe lesions when compared with the art of reporting images. In this book on imaging biomarkers, we tried to describe how quantitative imaging changes the way we should interact with other physicians and patients from the first idea to the final clinical application. Imaging biomarkers might generate spatially and time-resolved in vivo maps of the distribution of some relevant disease hallmarks in individual patients. The different chapters will deal with the shift in paradigm from descriptive signs and radiological findings toward a precision medicine where imaging plays a major role in the detection, grading, and localizat
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