Immunocyte density in parathyroid carcinoma is correlated with disease relapse
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ORIGINAL ARTICLE
Immunocyte density in parathyroid carcinoma is correlated with disease relapse Y. Hu1 · M. Cui1 · Y. Bi2 · X. Zhang1 · M. Wang1 · S. Hua1 · Q. Liao1 · Y. Zhao1 Received: 18 November 2019 / Accepted: 14 March 2020 © Italian Society of Endocrinology (SIE) 2020
Abstract Purpose Parathyroid carcinoma (PC) is an endocrine malignancy with a poor prognosis. The tumour immune microenvironment is a critical factor influencing the outcomes of multiple cancer types. However, knowledge of the immune microenvironment in PC remains limited. Methods The intratumoural density of immunocytes and the Ki-67 index were evaluated immunohistochemically in 51 PC patient samples and were compared with clinicopathological features and parafibromin staining results. The Kaplan–Meier method and Cox proportional hazards analysis were used to estimate the effects of these variables on clinical outcomes. Results Intratumoural immunocyte density was not correlated with age, gender, urolithiasis, or palpation of a neck mass. The Ki-67 index was correlated with the intratumoural density of CD3+ cells (P = 0.022) and CD8+ cells (P = 0.021) and serum calcium levels (P = 0.022). In the intratumoural area of primary foci, Kaplan–Meier method showed that the risk factors associated with recurrence/metastasis were a low density of C D3+ (P = 0.017), CD8+ (P = 0.019) and CD45+ cells + (P = 0.047), a high density of CD163 cells (P = 0.003) and a high Ki-67 index (P = 0.004). Cox regression multivariate analysis revealed that C D163+ cell density (hazard ratio (HR) 16.19, 95% confidence interval (CI) 1.99—131.66; P = 0.009) + and CD8 cell density (HR 0.13, 95% CI 0.02—0.76, P = 0.024) were independent factors associated with PC relapse. Conclusion The immune microenvironment is an important factor influencing the relapse of PC. The intratumoural density of CD3+, CD8+, CD45+, and C D163+ immunocytes was correlated with disease-free survival (DFS) in patients with PC. Immunotherapy based on T lymphocytes or tumour-associated macrophages may be a promising treatment strategy. Keywords Parathyroid carcinoma · Tumour-infiltrating immunocytes · Tumour-associated macrophage · T lymphocyte · Relapse
Introduction Y. Hu and M. Cui have contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40618-020-01224-6) contains supplementary material, which is available to authorized users. * Q. Liao [email protected] * Y. Zhao [email protected] 1
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
2
Parathyroid carcinoma (PC) is a type of rare malignant endocrine neoplasm with a poor prognosis. The incidence of PC has reportedly increased in the US and Finland in recent years [1, 2]. It accounts for less than 1
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