Immunohistochemistry in Tumor Diagnostics
This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics.Immunohistochemistry has become the most importan
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Immunohistochemistry in Tumor Diagnostics
Muin S.A. Tuffaha • Hans Guski Glen Kristiansen
Immunohistochemistry in Tumor Diagnostics
Muin S.A. Tuffaha Carl-Thiem-Klinikum Institut für Pathologie Cottbus Germany
Glen Kristiansen Universität Bonn, UKB Institut für Pathologie Bonn Germany
Hans Guski Vivantes Klinikum Neukölln Institut für Pathologie Berlin Germany
ISBN 978-3-319-53576-0 ISBN 978-3-319-53577-7 (eBook) DOI 10.1007/978-3-319-53577-7 Library of Congress Control Number: 2017941713 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
This book is dedicated to the memory of my father Sami and to the two great women in my life, my mother Haya and my wife Ayah.
Muin S.A. Tuffaha
Dedicated to my wife Maren, and daughters Maren and Silja who all are involved in human medicine.
Hans Guski
Dedicated to my wife Ilka and to our children Charlotte, Clara and Karl for their support and patience.
Glen Kristiansen
Contents
1 Immunohistochemistry in Tumor Diagnostics. . . . . . . . . . . . . . . . 1 1.1 Expression Pattern and Diagnostic Pitfalls ������������������������������ 1 1.2 Immunohistochemical Pathways for the Diagnosis Primary Tumors and of Metastasis of Unknown Primary Tumors������������������������������������������������������������������������ 2 References������������������������������������������������������������������������������������������ 9 Common Immunohistochemical Markers, Diagnostic approach, Pitfalls and Immunoprofiles of Most Common Tumors 2 Immunohistochemical Markers for the Diagnosis of Epithelial Tumors. . . . . . . . . . . . . .
