Immunomodulatory and Anti-inflammatory Effect of p -Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammat
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Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats Samuel Joshua Pragasam,1 Vijayalakshmi Venkatesan,2 and MahaboobKhan Rasool1,3
ABSTRACT—In this study, p-coumaric acid was evaluated for its immunomodulatory and antiinflammatory properties in vivo. The immunomodulatory effect of p-coumaric acid (100 mg/kg body weight) was assessed by evaluating its effect on cell-mediated immune responses (delayed type hypersensitivity reaction), serum immunoglobulin levels, and macrophage phagocytic index in rats. The anti-inflammatory effects of p-coumaric acid (100 mg/kg body weight) were investigated by examining its effect on expression of tumor necrosis factor (TNF-α) in synovial tissue by immunofluorescence confocal microscopy and circulating immune complexes in serum of adjuvantinduced arthritic rats. The increased cell-mediated immune responses and macrophage phagocytic index observed in control rats were significantly reduced (p
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