Immunopathology in Toxicology and Drug Development Volume 1, Immunob
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and
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George A. Parker Editor
Immunopathology in Toxicology and Drug Development Volume 1, Immunobiology, Investigative Techniques, and Special Studies
Molecular and Integrative Toxicology
Series Editors Jamie DeWitt East Carolina University Greenville, NC, USA Sarah Blossom Arkansas Children’s Hospital Research Institute Little Rock, AR, USA
More information about this series at http://www.springer.com/series/8792
George A. Parker Editor
Immunopathology in Toxicology and Drug Development Volume 1, Immunobiology, Investigative Techniques, and Special Studies
Editor George A. Parker Charles River Laboratories, Inc. Durham, NC, USA
ISSN 2168-4219 ISSN 2168-4235 (electronic) Molecular and Integrative Toxicology ISBN 978-3-319-47375-8 ISBN 978-3-319-47377-2 (eBook) DOI 10.1007/978-3-319-47377-2 Library of Congress Control Number: 2016955830 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune sys
