Impact of maternal smoking on the infant gut microbiota and its association with child overweight: a scoping review
- PDF / 679,517 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 78 Downloads / 229 Views
REVIEW ARTICLE
Impact of maternal smoking on the infant gut microbiota and its association with child overweight: a scoping review Cara McLean1 · Shelly Jun2 · Anita Kozyrskyj2,3 Received: 14 March 2019 / Accepted: 13 June 2019 © Children’s Hospital, Zhejiang University School of Medicine 2019
Abstract Background Childhood obesity is a growing public health concern with evidence demonstrating that while infant exposure to maternal smoking is linked to low birth weight at birth, there is a rapid catch up in weight and increased risk of obesity in later life. This scoping review aims to synthesize up-to-date evidence on the impact of maternal smoking on the infant gut microbiota and its association with child overweight. Methods We conducted a PRISMA-compliant scoping review. Primary population-based cohort studies published between 1900 and April 2018 were included. Relevant publications were retrieved from seven databases: PubMed, Medline, Embase, Scopus, Biosis, Cochrane library, and Web of Science Core Collection. Results A total of three prospective cohort studies were included which utilized high-throughput 16S rRNA gene sequencing to assess the gut microbiota and included a total of 1277 infant/neonatal participants. Neonates exposed to environmental smoke had a higher relative abundance of Ruminococcus and Akkermansia. Infants exposed to environmental smoke during pregnancy or postnatally were found to have increased gut bacterial richness, particularly Firmicutes at 3 months of age, while 6-month-old infants born to smoking mothers had an increased abundance of Bacteroides and Staphylococcus. Elevated Firmicutes richness at 3 months of age was associated with elevated odds of child overweight and obesity at 1 and 3 years of age. Conclusion The limited evidence to date warrants further large scale, longitudinal studies to explore the impact of maternal smoking and environmental tobacco smoke on the infant gut microbiome and its relation to child overweight. Keywords Environmental tobacco smoke · Gut microbiota · Infants · Maternal smoking · Overweight
Introduction Childhood obesity is an epidemic that will affect 60 million children globally by 2020 [1]. Childhood overweight or obesity often persists into adulthood, and is associated Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12519-019-00278-8) contains supplementary material, which is available to authorized users. * Anita Kozyrskyj [email protected] 1
Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
2
Department of Pediatrics, University of Alberta, 3‑527 Edmonton Clinic Health Academy, 11405‑87 Avenue, Edmonton, AB T6G 1C9, Canada
3
School of Public Health, University of Alberta, Edmonton, Canada
with a higher risk of developing noncommunicable diseases [2]. Existing theories on childhood overweight and obesity, which suggest an imbalance between energy intake and expenditure, are now being challenged [3]. Evidence demonstrates that exposures d
Data Loading...
