Impact of pulmonary embolism on morbidity and mortality in patients undergoing pancreatic surgery
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ORIGINAL ARTICLE
Impact of pulmonary embolism on morbidity and mortality in patients undergoing pancreatic surgery Benjamin Müssle 1 & Nathalie Buck 1 & Stephanie Schade 1 & Marian Sommer 1 & Florian Oehme 1 & Andreas Bogner 1 & Sebastian Hempel 1 & Christoph Radosa 2 & Christoph Kahlert 1 & Marius Distler 1 & Jürgen Weitz 1 & Thilo Welsch 1 Received: 19 August 2020 / Accepted: 2 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Postoperative pulmonary embolism (PE) after pancreatic surgery is a potentially life-threatening complication. However, the magnitude of morbidity and mortality of PE is still uncertain. The present study aims to assess the incidence of PE after pancreatic surgery and analyze its impact on the outcome. Methods We conducted a retrospective study including all patients who underwent pancreatic resections between 2005 and 2017. The development of PE was analyzed for a 90-day period following surgery. Risk factors were evaluated using regression models. Results The study investigated 947 patients undergoing pancreatic surgery. Overall, 26 (2.7%) patients developed PE. The median body mass index (BMI) of patients with PE was significantly higher (28.1 kg/m2 [24.7–31.8] vs. 24.8 kg/m2 [22.4– 27.8], p < 0.001). Patients with PE had a significantly increased duration of the operation and more often underwent multivisceral resections. The lowest incidence of PE was found after distal or total pancreatectomy (2%). In median, PE occurred on the fifth postoperative day (interquartile range: 3–9). Increased BMI, duration of operation, and postoperative deep venous thrombosis were found to be multivariate risk factors for the development of PE. Importantly, postoperative complications (53.8% vs. 15.1%, p < 0.001) and the 30-day mortality rate were significantly increased in the PE group (19.2% vs. 3.3%, p < 0.001).
Benjamin Müssle and Nathalie Buck contributed equally to this work. Previous publication None of the information, neither in part nor the complete manuscript, has been published elsewhere. This manuscript is furthermore neither in part nor as complete manuscript under consideration for publication in any other journal. * Thilo Welsch [email protected]
Christoph Radosa [email protected]
Benjamin Müssle [email protected]
Christoph Kahlert [email protected]
Nathalie Buck [email protected]
Marius Distler [email protected]
Stephanie Schade [email protected]
Jürgen Weitz [email protected]
Marian Sommer [email protected] 1
Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, P.O. Box 01307, Dresden, Germany
2
Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, P.O. Box
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