Impact of real-time angiographic co-registered optical coherence tomography on percutaneous coronary intervention: the O
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ORIGINAL PAPER
Impact of real‑time angiographic co‑registered optical coherence tomography on percutaneous coronary intervention: the OPTICO‑integration II trial Vera S. Schneider1,2 · Felix Böhm1,2 · Katharina Blum1 · Matthias Riedel1,2 · Youssef S. Abdelwahed1,2,3 · Jens Klotsche4 · Julia K. Steiner1,2 · Andrea Heuberger1,2 · Carsten Skurk1,2 · Hans‑Christian Mochmann1 · Alexander Lauten1,2 · Georg Fröhlich1,2 · Ursula Rauch‑Kröhnert1,2 · Arash Haghikia1,2,3 · David Sinning1 · Barbara E. Stähli1,2 · Ulf Landmesser1,2,3 · David M. Leistner1,2,3 Received: 6 July 2020 / Accepted: 27 August 2020 © The Author(s) 2020
Abstract Aims Longitudinal geographic mismatch (LGM) as well as edge dissections are associated with an increased risk of adverse events after percutaneous coronary intervention (PCI). Recently, a novel system of real-time optical coherence tomography (OCT) with angiographic co-registration (ACR) became available and allows matched integration of cross-sectional OCT images to angiography. The OPTICO-integration II trial sought to assess the impact of ACR for PCI planning on the risk of LGM and edge dissections. Methods A total of 84 patients were prospectively randomized to ACR-guided PCI, OCT-guided PCI (without co-registration), and angiography-guided PCI. Primary endpoint was a composite of major edge dissection and/or LGM as assessed by post-PCI OCT. Results The primary endpoint was significantly reduced in ACR-guided PCI (4.2%) as compared to OCT-guided PCI (19.1%; p = 0.03) and angiography-guided PCI (25.5%; p
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