In-silico study of hemodynamic effects in a coronary artery with stenosis
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part of Springer Nature, 2020 https://doi.org/10.1140/epjst/e2020-000128-2
THE EUROPEAN PHYSICAL JOURNAL SPECIAL TOPICS
Regular Article
In-silico study of hemodynamic effects in a coronary artery with stenosis Ilya O. Starodumov1,a , Felix A. Blyakhman2,3 , Sergey Yu. Sokolov2,3 , Ivan S. Bessonov4 , Andrey Yu. Zubarev2 , and Dmitri V. Alexandrov1 1
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Laboratory of Multi-Scale Mathematical Modeling, Department of Theoretical and Mathematical Physics, Ural Federal University, 620000 Ekaterinburg, Russia Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russia Ural State Medical University, 620028 Ekaterinburg, Russia Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, 625026 Tomsk, Russia Received 16 June 2020 / Accepted 10 September 2020 Published online 19 November 2020 Abstract. The paper presents a study of hemodynamic processes in an artery with stenosis. The Navier–Stokes model and the Carreau model for a non-Newtonian fluid are proposed for computer simulations. c Computational experiments were performed using the FlowVision software. The results of a test simulation for blood flow in the 2D tube, as well as a simulation for the native artery model, based on medical research data, are presented. The simulation results show that in a native artery with a stenosis, the distribution of blood velocity and viscosity may be asymmetric, and their local values differ significantly from the average values observed in the artery after the presumed revascularization. The results have great potential importance for diagnosing and treating arterial stenosis.
1 Introduction Coronary artery disease (CAD) is a leading cause of death in economically developed countries and is predicted to remain so for the next 20 years [1]. CAD is mainly associated with the artery atherosclerosis that damages the blood supply to the heart muscle and results in the development of ischemic heart disease (IHD). Medical therapy and the myocardial revascularization by the stenting of coronary arteries are the most introduced strategies for IHD treatment. Invasive coronary angiography is the current “gold standard” for the identification of CAD. Injection of a contrast agent into the circulatory system provides a good visualization of the location and relative degree of narrowing in the coronary arteries. In some cases, however, such information is not enough to develop an adequate strategy for patient treatment [2]. A decision regarding the treatment plane based on coronary angiography is often subjective. Generally, the correct decision should be based on an understanding of the extent to which narrowing of the artery lumen affects a
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The European Physical Journal Special Topics
the myocardial function. In other words, it is necessary to know the hemodynamic significance of a stenosis. To improve the accuracy of the planning of IHD treatment, many modern instrumental methods are implemented for the need
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