In utero exposure to influenza vaccine not associated with ASD in children
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In utero exposure to influenza vaccine not associated with ASD in children In utero exposure to influenza A virus vaccine H1N1 (H1N1 vaccine) is not associated with an increased risk of autism spectrum disorder (ASD) in children, according to findings of a Swedish study published in Annals of Internal Medicine.1 Cox regression analysis of Medical Birth Register data on live births in seven healthcare regions in Sweden between October 2009 and September 2010, Vaccination Register data on vaccinations in their mothers during pregnancy, and follow-up data on the birth cohort until December 2016, was used to investigate the association between in utero exposure to H1N1 vaccine in 39 736 infants (of whom 13 845 were exposed during the first trimester of pregnancy) and the risk of ASD or autistic disorder (AD), compared with 29 293 infants not exposed to the vaccine. Overall, 1.0% of children exposed to the vaccine in utero and 1.1% of unexposed children were diagnosed with ASD during follow-up. Adjusted regression analysis found no association between in utero exposure to H1N1 vaccine and the risk of ASD (adjusted hazard ratio [aHR] 0.95; 95% CI 0.81, 1.12) or AD (aHR 0.96; 95% CI 0.80, 1.16) diagnosis during childhood. There was also no association between exposure to the vaccine during the first trimester and the risk of diagnosis of ASD (aHR 0.92; 95% CI 0.74, 1.16) or AD (aHR 0.91; 95% CI 0.70, 1.18). "Ludvigsson and colleagues used Swedish register data to evaluate a hypothesized link between an AS03-adjuvanted influenza A/H1N1pdm09 vaccine used in pregnancy and later development of autism in offspring . . . Not surprisingly, the authors found no link," said Dr Anders Hviid from Statens Serum Institut, Copenhagen, Denmark, in an accompanying editorial published in Annals of Internal Medicine.2 "If pregnant women are offered COVID-19 vaccines, we must have observational studies in place that can promptly evaluate the overall safety of vaccination in pregnancy" and in their offspring during childhood, he commented. 1. Ludvigsson JF, et al. Maternal Influenza A(H1N1) Immunization During Pregnancy and Risk for Autism Spectrum Disorder in Offspring Annals of Internal Medicine : 1 Sep 2020. Available from: URL: https://doi.org/10.7326/M20-0167. 2. Hviid A. Vaccine Safety in Pregnancy: Going Beyond the Perinatal Period Annals of Internal Medicine : 1 Sep 2020. Available from: URL: https://doi.org/10.7326/ M20-5489. 803501184
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Reactions 12 Sep 2020 No. 1821
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