Rubella vaccine not associated with congenital rubella syndrome
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Rubella vaccine not associated with congenital rubella syndrome Rubella vaccination during pregnancy does not appear to be associated with congenital rubella syndrome (CRS) in neonates, according to findings of a systematic review and meta-analysis published in Vaccine. Databases were searched up to 1 August 2018 for studies reporting outcomes in women who received rubella-containing vaccines during pregnancy or within 3 months prior to pregnancy. Meta-analysis was used to assess associations between vaccination with monovalent rubella vaccines or combination rubellacontaining vaccines during pregnancy and potential harms to the foetus including CRS (cataracts, deafness and/or heart defects plus evidence of rubella infection). No cases of rubella vaccine-related CRS were reported in any of the identified studies. Based on data from four studies in inadvertently vaccinated pregnant women compared with unvaccinated women, with no cases of CRS reported, a theoretical risk of more than five additional cases of CRS per 1000 vaccinated women could be excluded. Based on studies in susceptible pregnant women who received rubella vaccination, the estimated maximum risk was one case of CRS per 1008 vaccinated women. Some cases of asymptomatic vaccine-related rubella infection in neonates were reported; the fixed effects estimate of the risk was 1.74% (95% CI 1.21, 2.28). "In summary from the evidence noted here no change is indicated in the current advice both that rubella vaccination in pregnancy should be avoided as a precaution, and that termination of pregnancy is however not advised if inadvertent vaccination in pregnancy does occur. No cases of CRS were observed with rubella vaccination but asymptomatic vaccine virus infection of the infant can occur," concluded the authors. Mangtani P, et al. Safety profile of rubella vaccine administered to pregnant women: A systematic review of pregnancy related adverse events following immunisation, including congenital rubella syndrome and congenital rubella infection in the foetus or infant. Vaccine : 12 Dec 2019. Available from: URL: 803442572 http://doi.org/10.1016/j.vaccine.2019.11.070
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Reactions 4 Jan 2020 No. 1785
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