In Vitro Neuronal Networks From Culturing Methods to Neuro-Technolog
This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental
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Michela Chiappalone Valentina Pasquale Monica Frega Editors
In Vitro Neuronal Networks
From Culturing Methods to NeuroTechnological Applications
Advances in Neurobiology Volume 22
Series Editor Arne Schousboe, Dept of Drug Design & Pharmacology, University of Copenhagen, Copenhagen, Denmark
More information about this series at http://www.springer.com/series/8787
Michela Chiappalone • Valentina Pasquale Monica Frega Editors
In Vitro Neuronal Networks From Culturing Methods to Neuro-Technological Applications
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Editors Michela Chiappalone Rehab Technologies IIT-INAIL Joint Lab Istituto Italiano di Tecnologia Genova, Italy
Valentina Pasquale Neuroscience and Brain Technologies Istituto Italiano di Tecnologia Genova, Italy
Monica Frega Department of Clinical Neurophysiology University of Twente Enschede, The Netherlands
ISSN 2190-5215 ISSN 2190-5223 (electronic) Advances in Neurobiology ISBN 978-3-030-11134-2 ISBN 978-3-030-11135-9 (eBook) https://doi.org/10.1007/978-3-030-11135-9 Library of Congress Control Number: 2019935515 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
This book is dedicated to our mentors
Preface
In vitro cultures of dissociated neurons coming from different brain areas retain important functional properties of the tissue of origin, thus representing a perfect trade-off between more realistic (but complex) experimental models and theoretical (but limited) modeling approaches. Moreover, the possibilities offered by the latest technologies allow the simultaneous monitoring of several units at high spatiotemporal resolution and for very long time periods, from hours to days and even months. These technological devel
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