Incidence and associated risk factors for limb amputation among sepsis survivors in South Korea
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ORIGINAL ARTICLE
Incidence and associated risk factors for limb amputation among sepsis survivors in South Korea Tak Kyu Oh1 · In‑Ae Song1 Received: 18 July 2020 / Accepted: 19 September 2020 © Japanese Society of Anesthesiologists 2020
Abstract Purpose Peripheral gangrene (PG) is a known complication requiring limb amputation among sepsis survivors; however, its incidence and associated risk factors remain controversial. We aimed to examine the incidence of limb amputation among sepsis survivors, and to investigate factors independently associated with limb amputation. Methods In this population-based cohort study, data obtained from the South Korean national health insurance service database between 2015 and 2016 were analyzed. A sepsis survivor was defined as someone having survived > 90 days after initiation of treatment for sepsis. Results Of 19,906 sepsis survivors, 163 (0.8%) had undergone surgical limb amputation. In a multivariable model, male sex (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.26–2.40; P = 0.001), dopamine infusion (OR 1.78, 95% CI 1.22–2.60; P = 0.003), epinephrine infusion (OR 2.04, 95% CI 1.30–3.20; P = 0.002), continuous renal replacement therapy (OR 3.34, 95% CI 2.01–3.20; P
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