Incorporation of NSAID Drug Gel Derived from Cellulose and Polyacrylamide
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Incorporation of NSAID Drug Gel Derived from Cellulose and Polyacrylamide Morales C. A.1, Castillo M. C.1, Díaz Z. N.1, González S. J. 1, Kharissova V. O.2 1 División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: [email protected] 2 Facultad de Ciencias Físico Matemáticas de la Universidad Autónoma de Nuevo León. ABSTRACT In this paper, the incorporation and release of two types of drugs was carried out in microgels of hydroxypropylcellulose/polyacrylamide (HPC/PAAM) and hydroxyethylcellulose/polyacrylamide (HEC/PAAM). The two drugs were NSAIDs (nonsteroidal, anti-inflammatory drugs)—one antipyretic and one analgesic—acetylsalicylic acid (aspirin, ASP) and iuprofen (IBU), respectively. First, the microgels were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FTIR) in order to identify the presence of functional groups for each polymer. The incorporation of the drug was made by swelling the microgels in a drug solution and finally carrying out the release of the substances listed at 37º C. The results were obtained by UV-visible spectroscopy. KEYWORDS: polymer, adsorption, biomedical INTRODUCTION A gel is a polymer system consisting of a three-dimensional network that has the ability to absorb a large amount of solvent. In the dry state, it is a solid and hard material; but, when it comes into contact with a solvent, it swells to absorb the liquid up to a physicochemical equilibrium [1]. The hydrogels are polymers that have particular characteristics: they are hydrophilic, insoluble in water, soft, elastic, and swell considerably in the presence of water, all the while maintaining their shape up to a physical-chemical equilibrium [2]. In recent years, considerable interest has been focused on hydrogels that undergo volume changes in response to small changes in environmental conditions around them [3]. This response can be attributed to the action of various external agents such as temperature, solvent composition, pH, irradiation with light at the appropriate wavelength, electric field, ionic strength, etc. [4]. This characteristic behavior, coupled with the biocompatibility, biodegradability, inert nature, mechanical properties, and chemical and thermal resistance, has opened the doors to a wide variety of technological applications in chemistry, medicine, environment, agriculture, and other fields of industry [5, 6]. A large number of systems for drug delivery are based on the use of synthetic polymers. These, for example, can be used for anchoring the drug. Within this group are the hydrogels, which are polymer matrices that swell in aqueous media by facilitating the release of the drug [7]. This research focuses on an application that has attracted considerable interest in science and focused on studying the ability to adapt these materials as conveyor systems in the mechanism for the sustained release of drugs. The main objective of the c
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