Inducible Enzymes in the Inflammatory Response
This volume will be of great value to all those researchers in the area of the inflam matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely n
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PLiVA Research Institute Prilaz baruna Filipovica 25 10000 Zagreb Croatia
Inducible Enzymes in the Inflammatory Response
Derek A. Willoughby Annetle Tomlinson Editors
Springer Basel AG
Editors Prof. Derek A. Willoughby Dr. Annetle Tomlinson Department of Experimental Pathology St. Bartholomew's and The Royal London School of Medicine and Dentistry Charterhouse Square London, EC1 M 6BQ
UK
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data Induclble enzymes In the Inflammatory response / ed. by DA Willoughby, A. Tomlinson - Basel ; Boston; Berlin : Birkhăuser, 1999 (progress in inflammation research)
ISBN 978-3-0348-9755-6 ISBN 978-3-0348-8747-2 (eBook) DOI 10.1007/978-3-0348-8747-2
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained.
© 1999 Springer Basel AG Originally published by Birkhăuser Verlag in 1999
Softcover reprint of the hardcover lSt edition 1999 Printed on acid-free paper produced from chlorine-free pulp. TCF = Cover design: Markus Etlerich, Basel ISBN 978-3-0348-9755-6
987654321
Contents
List of contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..
vii
Preface............................................................................
ix
Michel Pairet, Joanne van Rhyn and Manuel Distel Overview of COX-2 in inflammation: from the biology to the clinic.............
1
Adrian J. Hobbs and Salvador Moncada Inducible nitric oxide synthase and inflammation................................ 31 Dean Willis Overview of HO-1 in inflammatory pathologies ................................. 55 Vivienne R. Winrow and David R. Blake Inducible enzymes in the pathogenesis of rheumatoid arthritis. . . . . . . . . . . . . . . . .. 93 Lee D.K. Buttery and Julia M. Polak iNOS and COX-2 in atherosclerosis .............................................. 109 Michael P. Seed, Derek Gilroy, Mark Paul-Clark, Paul R. Colville-Nash, Dean Willis, Annette Tomlinson and Derek A. Willoughby The role of the inducible enzymes cyclooxygenase-2, nitric oxide synthase and heme oxygenase in angiogenesis of inflammation ........................... 125 Sergio H. Ferreira, Fernando Q. Cunha and St
